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Heavy ion radiation-based mutation breeding driven by multi-technology integration: from mechanism to application
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Xiaopeng GUO1, 2, Shuhan ZHANG2, Chenglin JIA1, Miaomiao ZHANG1, 3, Dong LU1, 3
Acta Microbiologica Sinica | 2026, 66(4) : 1569 - 1584
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Acta Microbiologica Sinica | 2026, 66(4): 1569-1584
• Review •
Heavy ion radiation-based mutation breeding driven by multi-technology integration: from mechanism to application
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Xiaopeng GUO1, 2, Shuhan ZHANG2, Chenglin JIA1, Miaomiao ZHANG1, 3, Dong LU1, 3
Affiliations
  • 1.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China
  • 2.School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, Gansu, China
  • 3.Key Laboratory of Microbial Resources Exploitation and Application of Gansu Province, Lanzhou, Gansu, China
Published: 2026-04-04 doi: 10.13343/j.cnki.wsxb.20250780
Outline
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Heavy ion radiation (HIR) is effective for generating new germplasm in plants and microorganisms due to its high mutation induction rate, broad mutagenesis spectrum, and excellent stability of mutants. However, the random mutagenesis induced by radiation limits the efficiency and quality of HIR-based mutation breeding, which has become a key problem to be tackled. According to the process of heavy ion radiation-based mutation breeding, this review proposes a set of tandem strategies to enable efficient and high-quality HIR-based mutation breeding practices. These strategies include adjusting the radiation parameters from multiple dimensions, regulating cellular sensitivity to radiation damage and damage repair capacity, combining heavy ion radiation with adaptive laboratory evolution, integrating heavy ion radiation with other mutagenic agents, adopting progressive radiation, formulating high-throughput screening schemes for mutants, and efficiently identifying, verifying, and integrating positive mutations. These strategies aim to improve the mutagenesis rate, screening efficiency, and utilization of positive mutations. Meanwhile, we envision a mutation breeding workstation that integrates a series of strategies to form a complete cycle for heavy-ion radiation-based mutation breeding. This study is expected to provide valuable insights for creating high-quality microbial resources through heavy-ion radiation.

heavy ion radiation  /  mutation breeding  /  efficient mutation induction  /  high-throughput screening  /  positive mutation mining  /  integrated workstation
Xiaopeng GUO, Shuhan ZHANG, Chenglin JIA, Miaomiao ZHANG, Dong LU. Heavy ion radiation-based mutation breeding driven by multi-technology integration: from mechanism to application[J]. Acta Microbiologica Sinica, 2026 , 66 (4) : 1569 -1584 . DOI: 10.13343/j.cnki.wsxb.20250780
Funding
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  • National Natural Science Foundation of China(12205132)
  • National Natural Science Foundation of China(12575386)
  • National Natural Science Foundation of China(12575382)
  • Key Research and Development Project of Gansu Province(25YFGA008)
  • 77th Batch of General Funding from China Postdoctoral Science Foundation(2025MD774059)
  • Joint Fund General Project of Gansu Province(25JRRA1148)
Appendix
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Year 2026 volume 66 Issue 4
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142
60
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Article Info
doi: 10.13343/j.cnki.wsxb.20250780
  • Receive Date：2025-10-17
  • Online Date：2026-04-14
  • Published：2026-04-04
Article Data
Affiliations
History
  • Received：2025-10-17
  • Accepted：2025-12-16
Funding
National Natural Science Foundation of China(12205132)
National Natural Science Foundation of China(12575386)
National Natural Science Foundation of China(12575382)
Key Research and Development Project of Gansu Province(25YFGA008)
77th Batch of General Funding from China Postdoctoral Science Foundation(2025MD774059)
Joint Fund General Project of Gansu Province(25JRRA1148)
Affiliations
    1.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China
    2.School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, Gansu, China
    3.Key Laboratory of Microbial Resources Exploitation and Application of Gansu Province, Lanzhou, Gansu, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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