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Research progress in metabolites of microorganisms in high-salt environments
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Xin WANG1, 2, Huixia NING1, Waili Aihemiding·1, Yili Abulimit·1
Acta Microbiologica Sinica | 2026, 66(4) : 1585 - 1599
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Acta Microbiologica Sinica | 2026, 66(4): 1585-1599
• Review •
Research progress in metabolites of microorganisms in high-salt environments
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Xin WANG1, 2, Huixia NING1, Waili Aihemiding·1, Yili Abulimit·1
Affiliations
  • 1.Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang, China
  • 2.College of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi, Xinjiang, China
Published: 2026-04-04 doi: 10.13343/j.cnki.wsxb.20250928
Outline
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Microorganisms in high-salt environments (including halophilic and halotolerant bacteria) are widely distributed in extreme habitats such as salt lakes, oceans, and saline soils. Due to their unique metabolic adaptation mechanisms, they have become an important source of structurally novel natural products. This article outlines their taxonomic status and ecological distribution, with a focus on summarizing the chemical structures of compatible solutes such as ectoine and glycine betaine among primary metabolites, and their core roles in osmotic pressure regulation and biomacromolecule protection. The structural types of secondary metabolites, including alkaloids, terpenoids, steroids, and polyketides, are systematically reviewed. Furthermore, this article summarizes the biological activities such as antibacterial, antitumor, antioxidant, enzyme inhibitory, and photoprotective effects and discusses the structure-activity relationships of secondary metabolites. Considering the unique properties of these metabolites, this article analyzes their application prospects in fields such as medicine and health, biomaterials, and environmental remediation. This review aims to provide a theoretical reference for the in-depth development of microbial resources in high-salt environments and the discovery of novel bioactive molecules.

microorganisms in high-salt environments  /  halophilic bacteria  /  metabolites  /  compatible solutes  /  biological activity  /  application prospects
Xin WANG, Huixia NING, Waili Aihemiding·, Yili Abulimit·. Research progress in metabolites of microorganisms in high-salt environments[J]. Acta Microbiologica Sinica, 2026 , 66 (4) : 1585 -1599 . DOI: 10.13343/j.cnki.wsxb.20250928
Funding
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  • Natural Science Foundation of Xinjiang Uygur Autonomous Region(2023D01A02)
  • West Light Foundation of the Chinese Academy of Sciences(2021-XBQNXZ-026)
Appendix
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Year 2026 volume 66 Issue 4
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127
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Article Info
doi: 10.13343/j.cnki.wsxb.20250928
  • Receive Date：2025-12-14
  • Online Date：2026-04-14
  • Published：2026-04-04
Article Data
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History
  • Received：2025-12-14
  • Accepted：2024-02-24
Funding
Natural Science Foundation of Xinjiang Uygur Autonomous Region(2023D01A02)
West Light Foundation of the Chinese Academy of Sciences(2021-XBQNXZ-026)
Affiliations
    1.Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang, China
    2.College of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi, Xinjiang, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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