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Research progress in pathogenicity of two human Pegiviruses
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Shuyi CHEN1, Zhengwei WAN2, Li QIU1, Haiying WANG2, *
Acta Microbiologica Sinica | 2025, 65(1) : 62 - 72
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Acta Microbiologica Sinica | 2025, 65(1): 62-72
• Reviews •
Research progress in pathogenicity of two human Pegiviruses
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Shuyi CHEN1, Zhengwei WAN2, Li QIU1, Haiying WANG2, *
Affiliations
  • 1 Guangzhou Women's and Children's Medical Centre, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
  • 2 School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China
Published: 2025-01-04 doi: 10.13343/j.cnki.wsxb.20240417
Outline
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The first human Pegivirus (HPgV-1) and the second human Pegivirus (HPgV-2) are the only two human Pegiviruses that have been identified until now. They share some common features including similar viral genome structure and low pathogenicity, while they also represent unique biological characteristics. HPgV-1 is called "good virus" because of its ability to slow down disease progression and reduce disease severity when co-infecting with HIV and Ebola virus. In addition, HPgV-1 was recently found to be related with lymphoma and neurological diseases. Therefore, HPgV-1 might be a possible breakthrough point in the treatment of refractory diseases caused by HIV and other viruses. HPgV-2 was firstly discovered from the plasma of a hepatitis C virus (HCV)-infected patient in 2015 and was found to always co-infect with HCV but hardly infect healthy people. However, the underlying mechanism of HPgV-2 and HCV co-infection remains to be elucidated. Distinct from most of RNA viruses, HPgV-2 exhibits low genomic diversity with high sequence identity and low intra-host variation, which give the implication of HPgV-2 as an excellent model for studying the mechanisms of viral genome variations. In conclusion, the human Pegiviruses are worthy of sustaining attention and study.

human Pegivirus  /  the first human Pegivirus (HPgV-1)  /  the second human Pegivirus (HPgV-2)  /  pathogenicity
Shuyi CHEN, Zhengwei WAN, Li QIU, Haiying WANG. Research progress in pathogenicity of two human Pegiviruses[J]. Acta Microbiologica Sinica, 2025 , 65 (1) : 62 -72 . DOI: 10.13343/j.cnki.wsxb.20240417
Funding
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  • Natural Science Foundation of Guangdong Province(2019A1515010148)
  • Natural Science Foundation of Guangdong Province(2024A1515030275)
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Year 2025 volume 65 Issue 1
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Article Info
doi: 10.13343/j.cnki.wsxb.20240417
  • Receive Date：2024-07-10
  • Online Date：2026-03-21
  • Published：2025-01-04
Article Data
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History
  • Received：2024-07-10
  • Accepted：2024-11-02
Funding
Natural Science Foundation of Guangdong Province(2019A1515010148)
Natural Science Foundation of Guangdong Province(2024A1515030275)
Affiliations
    1 Guangzhou Women's and Children's Medical Centre, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
    2 School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China

Corresponding:

*WANG Haiying, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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