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Research progress in tigecycline resistance genes tet(X) in Acinetobacter spp.
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Chong CHEN1, 2, *, Yilin LÜ1, 2, Taotao WU1, 2, Jing LIU1, 2
Acta Microbiologica Sinica | 2025, 65(1) : 29 - 37
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Acta Microbiologica Sinica | 2025, 65(1): 29-37
• Reviews •
Research progress in tigecycline resistance genes tet(X) in Acinetobacter spp.
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Chong CHEN1, 2, *, Yilin LÜ1, 2, Taotao WU1, 2, Jing LIU1, 2
Affiliations
  • 1 Institutes of Agricultural Science and Technology Development (Joint International Research Laboratory of Agriculture and Agri-product Safety), Yangzhou University, Yangzhou 225009, Jiangsu, China
  • 2 College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, Jiangsu, China
Published: 2025-01-04 doi: 10.13343/j.cnki.wsxb.20240439
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Acinetobacter spp. are the common opportunistic pathogens worldwide and pose a threat to the health of humans and animals. As the resistance rate to carbapenems aggravates, tigecycline has become one of the last lines for the treatment of multidrug-resistant Acinetobacter spp. infection. The rapid dissemination of tigecycline resistance genes tet(X3), tet(X4), tet(X5), tet(X6), and other variants in recent years has seriously affected the clinical application of new tetracycline antibiotics such as tigecycline, eravacycline, and omadacycline, whereas there is a lack of review on the tet(X) genes in Acinetobacter spp. This article comprehensively expounds the mechanisms of action, epidemiological characteristics, transmission risks, and inhibitors of tet(X) genes in Acinetobacter spp. and evaluates the diversity of their variants, bacterial hosts, geographical distribution, and sampling sources, aiming to provide a theoretical basis for the prevention and control of tet(X)-positive Acinetobacter spp.

Acinetobacter  /  tet(X)  /  insertion sequence common region 2 (ISCR2)  /  inhibitor
Chong CHEN, Yilin LÜ, Taotao WU, Jing LIU. Research progress in tigecycline resistance genes tet(X) in Acinetobacter spp.[J]. Acta Microbiologica Sinica, 2025 , 65 (1) : 29 -37 . DOI: 10.13343/j.cnki.wsxb.20240439
Funding
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  • National Natural Science Foundation of China(32402890)
  • Natural Science Foundation of Jiangsu Province(BK20210803)
  • China Postdoctoral Science Foundation(2023M732993)
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Year 2025 volume 65 Issue 1
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Article Info
doi: 10.13343/j.cnki.wsxb.20240439
  • Receive Date：2024-07-18
  • Online Date：2026-03-21
  • Published：2025-01-04
Article Data
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History
  • Received：2024-07-18
  • Accepted：2024-11-01
Funding
National Natural Science Foundation of China(32402890)
Natural Science Foundation of Jiangsu Province(BK20210803)
China Postdoctoral Science Foundation(2023M732993)
Affiliations
    1 Institutes of Agricultural Science and Technology Development (Joint International Research Laboratory of Agriculture and Agri-product Safety), Yangzhou University, Yangzhou 225009, Jiangsu, China
    2 College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, Jiangsu, China

Corresponding:

*CHEN Chong, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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