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Structural basis and catalytic mechanism of bacterial ADP-ribosyl hydrolases
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Yindi JIAO1, Luhao ZHANG2, Songying OUYANG1, 3, Hongxin GUAN1, *
Acta Microbiologica Sinica | 2025, 65(1) : 38 - 51
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Acta Microbiologica Sinica | 2025, 65(1): 38-51
• Reviews •
Structural basis and catalytic mechanism of bacterial ADP-ribosyl hydrolases
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Yindi JIAO1, Luhao ZHANG2, Songying OUYANG1, 3, Hongxin GUAN1, *
Affiliations
  • 1 College of Life Sciences, Fujian Normal University, Fuzhou 350117, Fujian, China
  • 2 College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350117, Fujian, China
  • 3 FJNU Biomedical Research Center of South China, Fujian Normal University, Fuzhou 350117, Fujian, China
Published: 2025-01-04 doi: 10.13343/j.cnki.wsxb.20240512
Outline
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Adenosine diphosphate-ribosylation (ADPr) is a reversible post-translational modification that is catalyzed by adenosine diphosphate-ribosyltransferases (ARTs) and adenosine diphosphate- ribosylhydrolases (ARHs), and it widely occurs in eukaryotes and prokaryotes. ARHs are a class of key enzymes that can reverse ADPr modification of specific amino acid residues or specific sites/sequences of DNA and RNA. They can regulate the physiological metabolism, signal transduction, gene expression, and other key life processes in bacteria or hosts, playing an important role in the inter/intraspecific competition, stress responses, and pathogenicity of bacteria. This article reviews the classification, structural characteristics, and catalytic mechanisms of bacterial ARHs, aiming to enrich our understanding about the catalytic mechanisms and biological functions of ARHs in bacterial life.

ADP-ribosylhydrolases  /  structural basis  /  catalytic mechanism
Yindi JIAO, Luhao ZHANG, Songying OUYANG, Hongxin GUAN. Structural basis and catalytic mechanism of bacterial ADP-ribosyl hydrolases[J]. Acta Microbiologica Sinica, 2025 , 65 (1) : 38 -51 . DOI: 10.13343/j.cnki.wsxb.20240512
Funding
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  • National Natural Science Foundation of China(82225028)
  • National Natural Science Foundation of China(82172287)
  • National Natural Science Foundation of China(31900879)
  • National Natural Science Foundation of China(32171265)
  • National Key Research and Development Program of China(2021YFC2301403)
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Year 2025 volume 65 Issue 1
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111
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Article Info
doi: 10.13343/j.cnki.wsxb.20240512
  • Receive Date：2024-08-19
  • Online Date：2026-03-21
  • Published：2025-01-04
Article Data
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History
  • Received：2024-08-19
  • Accepted：2024-10-14
Funding
National Natural Science Foundation of China(82225028)
National Natural Science Foundation of China(82172287)
National Natural Science Foundation of China(31900879)
National Natural Science Foundation of China(32171265)
National Key Research and Development Program of China(2021YFC2301403)
Affiliations
    1 College of Life Sciences, Fujian Normal University, Fuzhou 350117, Fujian, China
    2 College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350117, Fujian, China
    3 FJNU Biomedical Research Center of South China, Fujian Normal University, Fuzhou 350117, Fujian, China

Corresponding:

*GUAN Hongxin, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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