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Research progress in bacterial galactose metabolic pathway and its impacts on bacterial virulence
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Jiajia ZHENG, Song XUE, Qingqing YANG, Rendong FANG, Xuefeng CAO*
Acta Microbiologica Sinica | 2025, 65(1) : 17 - 28
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Acta Microbiologica Sinica | 2025, 65(1): 17-28
• Reviews •
Research progress in bacterial galactose metabolic pathway and its impacts on bacterial virulence
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Jiajia ZHENG, Song XUE, Qingqing YANG, Rendong FANG, Xuefeng CAO*
Affiliations
  • Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China
Published: 2025-01-04 doi: 10.13343/j.cnki.wsxb.20240488
Outline
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Galactose is a ubiquitous monosaccharide in nature, serving not only as a primary carbon source for bioenergy metabolism but also as a precursor for various biological synthesis reactions. In eukaryotic cells, galactose or its derivatives can act as signaling molecules to participate in intercellular communication. Recent studies have revealed that galactose can modulate bacterial virulence by regulating intracellular signal transduction. Accordingly, galactose is considered an underappreciated environmental regulator in bacterial infection. However, the specific regulatory mechanisms remain incompletely elucidated. This review integrates the latest research findings to summarize the bacterial galactose metabolic pathway, the biological implications of galactose metabolism in bacterial virulence and interactions with hosts, and the key proteins (enzymes) in the galactose metabolism pathway as potential targets for developing novel vaccines. It offers new insights and reference for comprehending bacterial infection mechanisms and exploring innovative antibacterial strategies.

galactose  /  bacteria  /  metabolic pathway  /  virulence regulation
Jiajia ZHENG, Song XUE, Qingqing YANG, Rendong FANG, Xuefeng CAO. Research progress in bacterial galactose metabolic pathway and its impacts on bacterial virulence[J]. Acta Microbiologica Sinica, 2025 , 65 (1) : 17 -28 . DOI: 10.13343/j.cnki.wsxb.20240488
Funding
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  • National Natural Science Foundation of China(32172850)
  • National Center of Technology Innovation for Pigs(NCTIP-XDIC17)
  • Fundamental Research Funds for the Central Universities(SWU-KQ23001)
  • Chongqing Modern Agricultural Industry Technology System(CQMAITS202312)
Appendix
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Year 2025 volume 65 Issue 1
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111
43
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Article Info
doi: 10.13343/j.cnki.wsxb.20240488
  • Receive Date：2024-08-05
  • Online Date：2026-03-21
  • Published：2025-01-04
Article Data
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History
  • Received：2024-08-05
  • Accepted：2024-10-28
Funding
National Natural Science Foundation of China(32172850)
National Center of Technology Innovation for Pigs(NCTIP-XDIC17)
Fundamental Research Funds for the Central Universities(SWU-KQ23001)
Chongqing Modern Agricultural Industry Technology System(CQMAITS202312)
Affiliations
    Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China

Corresponding:

*CAO Xuefeng, Tel: +86-23-46751547, E-mail:
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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