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Bifidobacterium adolescentis alleviates ulcerative colitis in mice
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Qianhao HOU1, Jingyi HU2, Zuanyuan HUANG2, Jinyuan ZHANG1, Xuejiao ZENG1, Xin LI1, Jiaqi LIN1, Yuling LI3, *, Lijun LIAO1, *
Acta Microbiologica Sinica | 2024, 64(12) : 4833 - 4849
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Acta Microbiologica Sinica | 2024, 64(12): 4833-4849
• Research Articles •
Bifidobacterium adolescentis alleviates ulcerative colitis in mice
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Qianhao HOU1, Jingyi HU2, Zuanyuan HUANG2, Jinyuan ZHANG1, Xuejiao ZENG1, Xin LI1, Jiaqi LIN1, Yuling LI3, *, Lijun LIAO1, *
Affiliations
  • 1 Department of Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China
  • 2 Xiamen Institutes of Respiratory Health, Xiamen 361000, Fujian, China
  • 3 Department of Pharmacy, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Published: 2024-08-28 doi: 10.13343/j.cnki.wsxb.20240402
Outline
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[Objective] To study the therapeutic effect of Bifidobacterium adolescentis strains with strong antioxidant capacity on a mouse model of ulcerative colitis (UC). [Methods] The B. adolescentis strains with strong antioxidant capacity were screened based on 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging rate, reducing capacity, and hydrogen peroxide tolerance. Subsequently, we established a mouse model of dextran sulfate sodium (DSS)-induced colitis to investigate the alleviating effects of the B. adolescentis strains with strong antioxidant capacity on UC. [Results] Among the 26 strains of B. adolescentis, TH02767, TH03658, and TH03664 demonstrated strong antioxidant capacity. Only TH02767 showed an alleviating effect on UC in terms of disease activity index and spleen index in the mouse model (P < 0.05). Moreover, the intervention with TH02767 lowered the levels of tumor necrosis factor-α, interleukin-6, interleukin-1β, and myeloperoxidase (P < 0.05), while enhancing the production of interleukin-10 (P < 0.05) in the colon. In addition, TH02767 modulated gut microbiota in the mice by reducing the relative abundance of Deferribacterota and increasing the relative abundance of Bacteroidetes. At the genus level, it increased the relative abundance of Muribaculum and Muribaculaceae (P < 0.05). [Conclusion] B. adolescentis TH02767 screened out in this study for its robust antioxidant capacity not only ameliorates the clinical symptoms associated with DSS-induced colitis in mice but also significantly reduces the levels of pro-inflammatory cytokines and modulates the gut microbiota.

Bifidobacterium adolescentis  /  antioxidant capacity  /  ulcerative colitis  /  dextran sodium sulfate  /  gut microbiota
Qianhao HOU, Jingyi HU, Zuanyuan HUANG, Jinyuan ZHANG, Xuejiao ZENG, Xin LI, Jiaqi LIN, Yuling LI, Lijun LIAO. Bifidobacterium adolescentis alleviates ulcerative colitis in mice[J]. Acta Microbiologica Sinica, 2024 , 64 (12) : 4833 -4849 . DOI: 10.13343/j.cnki.wsxb.20240402
Funding
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  • Academic Medicine Leader's Training Program in Health Systems of Pudong New Area(PWRd2020-06)
  • Shanghai's 2023 "Technology Innovation Action Plan" Medical Innovation Research Project(23Y11908300)
  • National Natural Science Foundation of China(82202401)
  • Shanghai Pudong New Area Summit (Emergency Medicine and Critical Care) Construction Project(PWYgf2021-03)
Appendix
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Year 2024 volume 64 Issue 12
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120
47
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Article Info
doi: 10.13343/j.cnki.wsxb.20240402
  • Receive Date：2024-07-01
  • Online Date：2026-03-21
  • Published：2024-08-28
Article Data
Affiliations
History
  • Received：2024-07-01
  • Accepted：2024-08-26
Funding
Academic Medicine Leader's Training Program in Health Systems of Pudong New Area(PWRd2020-06)
Shanghai's 2023 "Technology Innovation Action Plan" Medical Innovation Research Project(23Y11908300)
National Natural Science Foundation of China(82202401)
Shanghai Pudong New Area Summit (Emergency Medicine and Critical Care) Construction Project(PWYgf2021-03)
Affiliations
    1 Department of Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China
    2 Xiamen Institutes of Respiratory Health, Xiamen 361000, Fujian, China
    3 Department of Pharmacy, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China

Corresponding:

*E-mail: LI Yuling,
E-mail: LIAO Lijun,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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