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Advances in biosynthetic pathways, enzymes, and fermentation strain modification of acarbose
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Yuqing WANG1, Xian ZHANG1, Chuang LI1, 2, *, Zhenglian XUE1, 2, Xiangfei LI1, 2
Acta Microbiologica Sinica | 2024, 64(12) : 4760 - 4773
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Acta Microbiologica Sinica | 2024, 64(12): 4760-4773
• Reviews •
Advances in biosynthetic pathways, enzymes, and fermentation strain modification of acarbose
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Yuqing WANG1, Xian ZHANG1, Chuang LI1, 2, *, Zhenglian XUE1, 2, Xiangfei LI1, 2
Affiliations
  • 1 College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, Anhui, China
  • 2 Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, Wuhu 241000, Anhui, China
Published: 2024-09-25 doi: 10.13343/j.cnki.wsxb.20240414
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Acarbose, an α-glucosidase inhibitor, regulates the postprandial blood glucose level by competitively inhibiting the activities of sucrase, maltase, and glucamylase in the intestine, serving as an ideal drug ingredient with blood glucose-lowering activity. Acarbose is mainly produced by the fermentation of Actinoplanes sp., and its biosynthetic pathway is mainly divided into four modules: C7-cyclitol synthesis, deoxyglucosamine synthesis, maltose integration, and extracellular transport of acarbose and its homologues (carbophore cycle). This paper reviewed the advances in the research fields mentioned above, aiming to provide ideas for further exploring the biosynthetic pathways of acarbose, catalytic mechanisms of related enzymes, and molecular modification of fermentation strains.

acarbose  /  biosynthetic pathway  /  enzymes  /  strain modification  /  research advance
Yuqing WANG, Xian ZHANG, Chuang LI, Zhenglian XUE, Xiangfei LI. Advances in biosynthetic pathways, enzymes, and fermentation strain modification of acarbose[J]. Acta Microbiologica Sinica, 2024 , 64 (12) : 4760 -4773 . DOI: 10.13343/j.cnki.wsxb.20240414
Funding
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  • National Natural Science Foundation of China(32401039)
  • National Natural Science Foundation of China(32300059)
  • Open Project of Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding(ELMB-04)
Appendix
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Year 2024 volume 64 Issue 12
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125
52
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Article Info
doi: 10.13343/j.cnki.wsxb.20240414
  • Receive Date：2024-07-10
  • Online Date：2026-03-21
  • Published：2024-09-25
Article Data
Affiliations
History
  • Received：2024-07-10
  • Accepted：2024-09-24
Funding
National Natural Science Foundation of China(32401039)
National Natural Science Foundation of China(32300059)
Open Project of Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding(ELMB-04)
Affiliations
    1 College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, Anhui, China
    2 Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, Wuhu 241000, Anhui, China

Corresponding:

*LI Chuang, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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