PDF
Full
Outline
Escalating resistance of pathogens, especially Gram-negative bacteria, to antibiotics has become a public health problem arousing worldwide concern because of the abuse of antibiotics. The "Trojan Horse" strategy emerges as a promising approach to the development of new antibacterial agents. This strategy improves the antibacterial activity or broadens the antibacterial spectrum of antibiotics by using the siderophore-mediated bacterial iron transport system. In 2019, cefiderocol as the first siderophore-antibiotic conjugate was approved for marketing, which has garnered wide attention of scientists in this field. Currently, researchers mainly focus on siderophores or utilizing antibiotics with different mechanisms and ignoring linkers in the design of agents based on the "Trojan Horse" strategy. This review will summarize the impact of different linkers of conjugates on antibacterial activity, which could provide reference for the development of new antibacterial drugs and combating bacterial resistance.
PDF
102
42
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
