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Research progress of phages in prevention and treatment of bacterial biofilm-associated infections
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Lisha HE1, Zhuo YANG1, 2, Lei RAN1, 2, Hongwei CHEN1, 2, 3, 4, *, Hongzao YANG1, 2, 3, 4, *
Acta Microbiologica Sinica | 2024, 64(10) : 3670 - 3684
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Acta Microbiologica Sinica | 2024, 64(10): 3670-3684
• Reviews •
Research progress of phages in prevention and treatment of bacterial biofilm-associated infections
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Lisha HE1, Zhuo YANG1, 2, Lei RAN1, 2, Hongwei CHEN1, 2, 3, 4, *, Hongzao YANG1, 2, 3, 4, *
Affiliations
  • 1 College of Veterinary Medicine, Southwest University, Chongqing 402460, China
  • 2 National Center of Technology Innovation for Pigs, Chongqing 402460, China
  • 3 Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China
  • 4 Traditional Chinese Veterinary Research Institute, Southwest University, Chongqing 402460, China
Published: 2024-08-06 doi: 10.13343/j.cnki.wsxb.20240259
Outline
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Bacterial biofilms are aggregates surrounded by extracellular polymeric substances produced by bacteria, exhibiting significant resistance to antimicrobials and host immune defense mechanisms. As a result, they become a crucial factor in the recalcitrance of bacterial infections. Phages, as a class of viruses capable of specifically infecting and lysing bacteria, have demonstrated immense potential in the prevention and treatment of biofilm-associated infections. This review summarizes the efficacy, in vitro and in vivo research methods, and mechanisms of phages, phage endolysins, and phage-antibiotic combinations in combating biofilm-associated infections. Furthermore, it discusses the prospects and potential obstacles of phages in this field, aiming to give insights into the development of more effective therapeutic agents.

phage  /  bacterial biofilm  /  endolysin  /  phage-antibiotic combination therapy
Lisha HE, Zhuo YANG, Lei RAN, Hongwei CHEN, Hongzao YANG. Research progress of phages in prevention and treatment of bacterial biofilm-associated infections[J]. Acta Microbiologica Sinica, 2024 , 64 (10) : 3670 -3684 . DOI: 10.13343/j.cnki.wsxb.20240259
Funding
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  • Pilot Technology Project of National Center of Technology Innovation for Pigs(NCTIP-XD/B12)
  • Pilot Technology Project of National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
  • Fundamental Research Funds for the Central Universities(SWU-KQ22045)
  • Chongqing Technical Innovation and Application Development Special General Project(CSTB2023TIAD-LDX0006)
  • Science and Technology Cooperation Project of Shandong and Chongqing(2022LYXZ030)
  • Yunnan Province Science and Technology Department Key Research and Development Plan(202403AC100013)
Appendix
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Year 2024 volume 64 Issue 10
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153
73
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Article Info
doi: 10.13343/j.cnki.wsxb.20240259
  • Receive Date：2024-04-24
  • Online Date：2026-03-21
  • Published：2024-08-06
Article Data
Affiliations
History
  • Received：2024-04-24
  • Accepted：2024-08-02
Funding
Pilot Technology Project of National Center of Technology Innovation for Pigs(NCTIP-XD/B12)
Pilot Technology Project of National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
Fundamental Research Funds for the Central Universities(SWU-KQ22045)
Chongqing Technical Innovation and Application Development Special General Project(CSTB2023TIAD-LDX0006)
Science and Technology Cooperation Project of Shandong and Chongqing(2022LYXZ030)
Yunnan Province Science and Technology Department Key Research and Development Plan(202403AC100013)
Affiliations
    1 College of Veterinary Medicine, Southwest University, Chongqing 402460, China
    2 National Center of Technology Innovation for Pigs, Chongqing 402460, China
    3 Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China
    4 Traditional Chinese Veterinary Research Institute, Southwest University, Chongqing 402460, China

Corresponding:

*CHEN Hongwei, E-mail:
YANG Hongzao, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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