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Research progress on the mechanism of intracellular-induced expression of antimicrobial peptide LL-37
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Mengjie ZHANG1, Xiaofei LI2, Yunlu LI1, Xin'an JIAO3, Jinlin HUANG1, 2, 3, 4, *
Acta Microbiologica Sinica | 2024, 64(10) : 3647 - 3655
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Acta Microbiologica Sinica | 2024, 64(10): 3647-3655
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Research progress on the mechanism of intracellular-induced expression of antimicrobial peptide LL-37
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Mengjie ZHANG1, Xiaofei LI2, Yunlu LI1, Xin'an JIAO3, Jinlin HUANG1, 2, 3, 4, *
Affiliations
  • 1 Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • 2 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China
  • 3 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou 225009, Jiangsu, China
  • 4 Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education, Yangzhou 225009, Jiangsu, China
Published: 2024-07-04 doi: 10.13343/j.cnki.wsxb.20240244
Outline
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Innate immunity constitutes the first line of immune defense. As a part of the body's innate immunity, the antimicrobial peptide LL-37 plays a crucial role in maintaining homeostasis, with two primary functions: direct antimicrobial activity and immunomodulation. Currently, research on LL-37 mainly focuses on its function, while its induced expression in vivo has rarely been studied. However, understanding the induced expression of LL-37 is essential for delving into the body's immune defense mechanisms. Therefore, this paper briefly reviewed the research progress on the synthesis and functions of LL-37, the factors inducing its secretion, and the regulatory pathways involved in its induced expression. The aim is to offer new insights into the regulatory pathways and immune defense functions of LL-37 in the human body.

antimicrobial peptide LL-37  /  in vivo induction  /  regulatory pathways
Mengjie ZHANG, Xiaofei LI, Yunlu LI, Xin'an JIAO, Jinlin HUANG. Research progress on the mechanism of intracellular-induced expression of antimicrobial peptide LL-37[J]. Acta Microbiologica Sinica, 2024 , 64 (10) : 3647 -3655 . DOI: 10.13343/j.cnki.wsxb.20240244
Funding
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  • National Natural Science Foundation of China(32172939)
  • Yangzhou University Interdisciplinary Research Foundation for Veterinary Medicine Discipline of Targeted Support(yzuxk202003)
  • Yangzhou Key Research and Development Program (Social Development)(YZ2022059)
  • Taishan Industry Leading Talents Project in Shandong Province(tscy20190113)
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Year 2024 volume 64 Issue 10
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129
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Article Info
doi: 10.13343/j.cnki.wsxb.20240244
  • Receive Date：2024-04-16
  • Online Date：2026-03-21
  • Published：2024-07-04
Article Data
Affiliations
History
  • Received：2024-04-16
  • Accepted：2024-07-01
Funding
National Natural Science Foundation of China(32172939)
Yangzhou University Interdisciplinary Research Foundation for Veterinary Medicine Discipline of Targeted Support(yzuxk202003)
Yangzhou Key Research and Development Program (Social Development)(YZ2022059)
Taishan Industry Leading Talents Project in Shandong Province(tscy20190113)
Affiliations
    1 Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu, China
    2 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China
    3 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou 225009, Jiangsu, China
    4 Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education, Yangzhou 225009, Jiangsu, China

Corresponding:

*HUANG Jinlin, Tel: +86-514-87971136, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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