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Advances in the chemical structures and biosynthesis of capsular polysaccharides of Streptococcus pneumoniae
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Wenxu ZHAO1, 2, Fan YANG1, 2, Lei HUANG1, 2, Wenbo DONG1, 2, Jinghua YANG1, 2, *
Acta Microbiologica Sinica | 2024, 64(9) : 3168 - 3199
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Acta Microbiologica Sinica | 2024, 64(9): 3168-3199
• Reviews •
Advances in the chemical structures and biosynthesis of capsular polysaccharides of Streptococcus pneumoniae
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Wenxu ZHAO1, 2, Fan YANG1, 2, Lei HUANG1, 2, Wenbo DONG1, 2, Jinghua YANG1, 2, *
Affiliations
  • 1 Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
  • 2 University of Chinese Academy of Sciences, Beijing 101408, China
Published: 2024-04-15 doi: 10.13343/j.cnki.wsxb.20240120
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Streptococcus pneumoniae causes serious diseases such as pneumoniae and meningitis in humans. Capsular polysaccharides (CPSs) surrounding bacteria are not only key virulence factors but also major antigens. Therefore, CPSs have been prepared into polysaccharide vaccines and polysaccharide conjugate vaccines, which have greatly reduced the infection of pneumococci. CPSs are formed by polymerization of oligosaccharide repeating units which generally have 2−8 monosaccharides. CPSs present complex structures with diverse antigenic epitopes, being the basis of bacterial serotyping. Currently, 107 serotypes of S. pneumoniae have been identified. Each serotype has a unique CPS structure, a stable genetic basis, and specific serological characteristics. The diversity and constant changes of CPS structures explain the difficulty in the eradication of pneumococci. This review summarizes the known chemical structures of 95 CPSs and discusses the genetic basis, biosynthesis mechanism, and purification methods of CPSs. This review aims to enrich the knowledge about CPS diversity and provide a reference for probing into the functions and evolution of CPSs as well as for preparing polysaccharide vaccines.

Streptococcus pneumoniae  /  capsular polysaccharide  /  structure  /  biosynthesis mechanism  /  purification method
Wenxu ZHAO, Fan YANG, Lei HUANG, Wenbo DONG, Jinghua YANG. Advances in the chemical structures and biosynthesis of capsular polysaccharides of Streptococcus pneumoniae[J]. Acta Microbiologica Sinica, 2024 , 64 (9) : 3168 -3199 . DOI: 10.13343/j.cnki.wsxb.20240120
Funding
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  • National Natural Science Foundation of China(31972919)
  • National Key Research and Development Program of China for Synthetic Biology(2019YFA0905600)
Appendix
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Year 2024 volume 64 Issue 9
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Article Info
doi: 10.13343/j.cnki.wsxb.20240120
  • Receive Date：2024-02-27
  • Online Date：2026-03-20
  • Published：2024-04-15
Article Data
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History
  • Received：2024-02-27
  • Accepted：2024-04-09
Funding
National Natural Science Foundation of China(31972919)
National Key Research and Development Program of China for Synthetic Biology(2019YFA0905600)
Affiliations
    1 Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    2 University of Chinese Academy of Sciences, Beijing 101408, China

Corresponding:

*YANG Jinghua, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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