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Progress in the synthesis of L-threonine by metabolic engineering of Escherichia coli
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Xiaoping LUO1, 2, Buli SU2, Mingrong DENG2, Xiaolong XU1, Honghui ZHU2, *
Acta Microbiologica Sinica | 2024, 64(8) : 2648 - 2660
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Acta Microbiologica Sinica | 2024, 64(8): 2648-2660
• Reviews •
Progress in the synthesis of L-threonine by metabolic engineering of Escherichia coli
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Xiaoping LUO1, 2, Buli SU2, Mingrong DENG2, Xiaolong XU1, Honghui ZHU2, *
Affiliations
  • 1 School of Environmental and Chemical Engineering, Wuyi University, Jiangmen 529020, Guangdong, China
  • 2 State Key Laboratory of Applied Microbiology Southern China, Key Laboratory of Agricultural Microbiomics and Precision Application (MARA), Key Laboratory of Agricultural Microbiome (MARA), Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China
Published: 2024-05-29 doi: 10.13343/j.cnki.wsxb.20240078
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L-threonine is one of the eight essential amino acids that cannot be synthesized by the human body and must be taken from food. It is an important component of protein synthesis and is widely used in food, feed, medicine and other fields. At present, Escherichia coli can achieve a high threonine yield in fermentation, being the main bacterium used for industrial production of threonine. With the development of metabolic engineering, the modification of strains is no longer limited to mutagenesis, and the directed modification of strains greatly improves the production of L-threonine, facilitating the development of the L-threonine industry. This paper introduces the physicochemical properties and synthesis pathway of L-threonine and reviews the achievements in improving L-threonine production by metabolic engineering, aiming to enrich the knowledge about the modification of Escherichia coli for efficient synthesis of threonine.

L-threonine  /  Escherichia coli  /  metabolic regulation  /  precursor  /  cofactor
Xiaoping LUO, Buli SU, Mingrong DENG, Xiaolong XU, Honghui ZHU. Progress in the synthesis of L-threonine by metabolic engineering of Escherichia coli[J]. Acta Microbiologica Sinica, 2024 , 64 (8) : 2648 -2660 . DOI: 10.13343/j.cnki.wsxb.20240078
Funding
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  • National Key Research and Development Program of China(2021YFC2100900)
  • Guangdong Special Support Program(2021JC06N628)
  • GDAS Project of Science and Technology Development(2022GDASZH-2022010101)
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Year 2024 volume 64 Issue 8
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Article Info
doi: 10.13343/j.cnki.wsxb.20240078
  • Receive Date：2024-01-31
  • Online Date：2026-03-19
  • Published：2024-05-29
Article Data
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History
  • Received：2024-01-31
  • Accepted：2024-05-28
Funding
National Key Research and Development Program of China(2021YFC2100900)
Guangdong Special Support Program(2021JC06N628)
GDAS Project of Science and Technology Development(2022GDASZH-2022010101)
Affiliations
    1 School of Environmental and Chemical Engineering, Wuyi University, Jiangmen 529020, Guangdong, China
    2 State Key Laboratory of Applied Microbiology Southern China, Key Laboratory of Agricultural Microbiomics and Precision Application (MARA), Key Laboratory of Agricultural Microbiome (MARA), Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China

Corresponding:

*ZHU Honghui, Tel: +86-20-87685699, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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