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Research progress in gene regulation of Escherichia coli biofilm formation
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Chengjun MA1, 2, Jingjing LIU1, 2, Min JIAO1, 2, Hongzao YANG1, 2, 3, *, Hongwei CHEN1, 2, 3, *
Acta Microbiologica Sinica | 2024, 64(8) : 2623 - 2647
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Acta Microbiologica Sinica | 2024, 64(8): 2623-2647
• Reviews •
Research progress in gene regulation of Escherichia coli biofilm formation
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Chengjun MA1, 2, Jingjing LIU1, 2, Min JIAO1, 2, Hongzao YANG1, 2, 3, *, Hongwei CHEN1, 2, 3, *
Affiliations
  • 1 College of Veterinary Medicine, Southwest University, Chongqing 402460, China
  • 2 National Center of Technology Innovation for Pigs, Chongqing 402460, China
  • 3 Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China
Published: 2024-03-28 doi: 10.13343/j.cnki.wsxb.20240032
Outline
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Escherichia coli, a facultative anaerobic, flagellated, Gram-negative rod bacterium commonly parasitic in the intestines of humans and animals, is one of the common zoonotic pathogens. E. coli is easy to form biofilms, which are special aggregates formed by bacterial cells attached to each other and encased with self-produced extracellular matrix. Biofilm formation is a major reason for the difficulty in curing bacterial infectious diseases in clinical practice. It not only helps bacteria evade the host defense system but also reduces or prevents drugs from working, thereby inducing biofilm-associated infections (BAIs). This review introduces the molecular mechanism of E. coli biofilm formation from the perspective of the gene regulatory system and related regulatory proteins and summarizes the strategies for the prevention and treatment of BAIs, providing references for finding appropriate drug targets and preventing BAIs.

Escherichia coli  /  biofilm  /  gene regulation  /  biofilm-associated infections
Chengjun MA, Jingjing LIU, Min JIAO, Hongzao YANG, Hongwei CHEN. Research progress in gene regulation of Escherichia coli biofilm formation[J]. Acta Microbiologica Sinica, 2024 , 64 (8) : 2623 -2647 . DOI: 10.13343/j.cnki.wsxb.20240032
Funding
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  • National Center of Technology Innovation for Pigs(NCTIP-XD/B12)
  • National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
  • Chongqing Postgraduate Scientific Research Innovation Project(CSTB2023TIAD-LDX0006)
  • Chongqing Technical Innovation and Application Development Special General Project(SWU-KQ22045)
  • Fundamental Research Funds for the Central Universities(CYS22247)
  • Project of Shandong Province on the Transformation of Scientific and Technological Achievements(2022LYXZ030)
Appendix
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Year 2024 volume 64 Issue 8
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158
72
Cite this Article
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Article Info
doi: 10.13343/j.cnki.wsxb.20240032
  • Receive Date：2024-01-09
  • Online Date：2026-03-19
  • Published：2024-03-28
Article Data
Affiliations
History
  • Received：2024-01-09
  • Accepted：2024-03-15
Funding
National Center of Technology Innovation for Pigs(NCTIP-XD/B12)
National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
Chongqing Postgraduate Scientific Research Innovation Project(CSTB2023TIAD-LDX0006)
Chongqing Technical Innovation and Application Development Special General Project(SWU-KQ22045)
Fundamental Research Funds for the Central Universities(CYS22247)
Project of Shandong Province on the Transformation of Scientific and Technological Achievements(2022LYXZ030)
Affiliations
    1 College of Veterinary Medicine, Southwest University, Chongqing 402460, China
    2 National Center of Technology Innovation for Pigs, Chongqing 402460, China
    3 Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China

Corresponding:

*YANG Hongzao, E-mail:
CHEN Hongwei, E-mail:
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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