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Research progress in structures, mechanisms, and modification of antimicrobial peptides
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Chenyuan YANG1, Zichuan YU1, Di QIN2, Yuanyuan GAO3, *
Acta Microbiologica Sinica | 2024, 64(7) : 2242 - 2259
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Acta Microbiologica Sinica | 2024, 64(7): 2242-2259
• Reviews •
Research progress in structures, mechanisms, and modification of antimicrobial peptides
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Chenyuan YANG1, Zichuan YU1, Di QIN2, Yuanyuan GAO3, *
Affiliations
  • 1 School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, Shandong, China
  • 2 School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, Shandong, China
  • 3 School of Pharmacy, Shandong Second Medical University, Weifang 261053, Shandong, China
Published: 2024-07-04 doi: 10.13343/j.cnki.wsxb.20230812
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Bacterial infection has become one of the major problems threatening public health, and the abuse of antibiotics has accelerated the development of bacterial resistance. Antimicrobial peptides have attracted extensive attention due to their broad-spectrum antibacterial activity, rapid bactericidal effect, low toxicity, and low risk of drug resistance. However, the natural structures of antimicrobial peptides indicate some limitations, such as easy degradation, instability, low permeability, and high costs, in their application. How to improve antimicrobial peptides is still a problem to be solved. From the sources and structural characteristics of antimicrobial peptides, we analyzed the spatial structures related to the antibacterial activity and corresponding antibacterial mechanisms. In addition, we summarize the existing improvement strategies of antimicrobial peptides to lay a foundation for seeking new improvement schemes. This review provides new ideas and directions for the modification and clinical application of antimicrobial peptides in the future.

antimicrobial peptides  /  secondary structure  /  mechanism  /  modification  /  application for antibacterial purpose
Chenyuan YANG, Zichuan YU, Di QIN, Yuanyuan GAO. Research progress in structures, mechanisms, and modification of antimicrobial peptides[J]. Acta Microbiologica Sinica, 2024 , 64 (7) : 2242 -2259 . DOI: 10.13343/j.cnki.wsxb.20230812
Funding
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  • Natural Science Foundation of Shandong Province(ZR2022MH152)
Appendix
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Year 2024 volume 64 Issue 7
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Article Info
doi: 10.13343/j.cnki.wsxb.20230812
  • Receive Date：2023-12-31
  • Online Date：2026-03-19
  • Published：2024-07-04
Article Data
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History
  • Received：2023-12-31
  • Accepted：2024-04-23
Funding
Natural Science Foundation of Shandong Province(ZR2022MH152)
Affiliations
    1 School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, Shandong, China
    2 School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, Shandong, China
    3 School of Pharmacy, Shandong Second Medical University, Weifang 261053, Shandong, China

Corresponding:

*GAO Yuanyuan, E-mail:
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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