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Research progress in probiotics for prevention and treatment of atopic dermatitis
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Wanni WANG1, 2, Ying LI2, Jiahui ZENG2, Xinqiang XIE2, Qingping WU2, *
Acta Microbiologica Sinica | 2024, 64(5) : 1378 - 1391
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Acta Microbiologica Sinica | 2024, 64(5): 1378-1391
• Reviews •
Research progress in probiotics for prevention and treatment of atopic dermatitis
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Wanni WANG1, 2, Ying LI2, Jiahui ZENG2, Xinqiang XIE2, Qingping WU2, *
Affiliations
  • 1 School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi, China
  • 2 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China
Published: 2024-05-04 doi: 10.13343/j.cnki.wsxb.20230682
Outline
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Atopic dermatitis (AD) is a highly prevalent allergic skin disease characterised by recurrent attacks and severe itching. The pathogenesis of AD involves a variety of factors including genetic susceptibility, epidermal barrier dysfunction, microbiome dysbiosis, immune imbalance, and the environment, while the available therapeutic drugs have severe side effects and limited efficacy. Studies have demonstrated that gut microbiota, particularly probiotics, play a role in AD. Probiotics can alleviate AD symptoms by inhibiting pathogens, enhancing barriers, improving the intestinal environment, and balancing the Th1/Th2 immune response, among other mechanisms. In this review, we summarized the skin and intestinal microecological characteristics of AD patients and systematically elucidated the mechanisms of probiotics in alleviating AD from the pathogenesis and influencing factors of AD, aiming to provide theoretical support for probiotics in the treatment of AD and related allergic skin diseases.

atopic dermatitis  /  gut microbiota  /  immunity  /  probiotics  /  histamine
Wanni WANG, Ying LI, Jiahui ZENG, Xinqiang XIE, Qingping WU. Research progress in probiotics for prevention and treatment of atopic dermatitis[J]. Acta Microbiologica Sinica, 2024 , 64 (5) : 1378 -1391 . DOI: 10.13343/j.cnki.wsxb.20230682
Funding
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  • National Key Research and Development Program of China(2022YFD2100700)
  • Natural Science Foundation of Guangdong Province(2022A1515010946)
  • Key-Area Research and Development Program of Guangdong Province(2022B1111070006)
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Year 2024 volume 64 Issue 5
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Article Info
doi: 10.13343/j.cnki.wsxb.20230682
  • Receive Date：2023-11-06
  • Online Date：2026-03-19
  • Published：2024-05-04
Article Data
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History
  • Received：2023-11-06
  • Accepted：2024-02-20
Funding
National Key Research and Development Program of China(2022YFD2100700)
Natural Science Foundation of Guangdong Province(2022A1515010946)
Key-Area Research and Development Program of Guangdong Province(2022B1111070006)
Affiliations
    1 School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi, China
    2 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China

Corresponding:

*WU Qingping, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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