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Role of LPXTG-anchored protein Lmo0880 inListeriamonocytogenes infection
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Kechen LIN1, Haojie LI1, Xiuling ZHAO2, Si ZHOU1, Junhui LIAO1, Zinian WANG1, Gexuan JIN1, Fuxin ZHU1, Jiali XU1, Jing SUN1, Houhui SONG1, Simin DENG1, *, Changyong CHENG1, *
Acta Microbiologica Sinica | 2024, 64(3) : 893 - 906
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Acta Microbiologica Sinica | 2024, 64(3): 893-906
• Research Articles •
Role of LPXTG-anchored protein Lmo0880 inListeriamonocytogenes infection
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Kechen LIN1, Haojie LI1, Xiuling ZHAO2, Si ZHOU1, Junhui LIAO1, Zinian WANG1, Gexuan JIN1, Fuxin ZHU1, Jiali XU1, Jing SUN1, Houhui SONG1, Simin DENG1, *, Changyong CHENG1, *
Affiliations
  • 1 Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A & F University, Hangzhou 311300, Zhejiang, China
  • 2 Technical Center of Ningbo Customs, Ningbo Academy of Quarantine & Inspection Science and Technology, Ningbo 315000, Zhejiang, China
Published: 2024-03-04 doi: 10.13343/j.cnki.wsxb.20230597
Outline
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[Objective] To generateListeriamonocytogenes strains withlmo0880 deleted and complemented strains, so as to investigate the roles of Lmo0880 in bacterial infection in a host. [Methods] Thelmo0880-deleted strain was generated by homologous recombination, and the complementary strain was constructed by introducing an integrative plasmid carryinglmo0880 into thelmo0880-deleted strain. The growth, adhesion, invasion, and intracellular proliferation were compared between thelmo0880-deleted strain, complementary strain, and the wild type. [Results] The deletion oflmo0880 did not significantly impact bacterial growth or adhesion. However, it led to notable decreases in cell invasion, proliferation, and colonization in the liver and spleen, ultimately diminishing the pathogenicity in mice. [Conclusion] The LPXTG-anchored protein Lmo0880 plays a crucial role in bacterial invasion, proliferation, and colonization in a host. These findings provide a solid foundation for deeply understanding the pathogen-host interaction duringL.monocytogenes infection.

Listeriamonocytogenes  /  LPXTG-anchored protein Lmo0880  /  host infection
Kechen LIN, Haojie LI, Xiuling ZHAO, Si ZHOU, Junhui LIAO, Zinian WANG, Gexuan JIN, Fuxin ZHU, Jiali XU, Jing SUN, Houhui SONG, Simin DENG, Changyong CHENG. Role of LPXTG-anchored protein Lmo0880 inListeriamonocytogenes infection[J]. Acta Microbiologica Sinica, 2024 , 64 (3) : 893 -906 . DOI: 10.13343/j.cnki.wsxb.20230597
Funding
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  • National Natural Science Foundation of China(32002317)
  • National Natural Science Foundation of China(32302961)
  • Natural Science Foundation of Zhejiang Province(Q21C180006)
  • Natural Science Foundation of Zhejiang Province(LY23C180002)
  • Ningbo Natural Science Foundation(202003N4178)
Appendix
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Year 2024 volume 64 Issue 3
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Article Info
doi: 10.13343/j.cnki.wsxb.20230597
  • Receive Date：2023-09-21
  • Online Date：2026-03-19
  • Published：2024-03-04
Article Data
Affiliations
History
  • Received：2023-09-21
  • Accepted：2023-12-15
Funding
National Natural Science Foundation of China(32002317)
National Natural Science Foundation of China(32302961)
Natural Science Foundation of Zhejiang Province(Q21C180006)
Natural Science Foundation of Zhejiang Province(LY23C180002)
Ningbo Natural Science Foundation(202003N4178)
Affiliations
    1 Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A & F University, Hangzhou 311300, Zhejiang, China
    2 Technical Center of Ningbo Customs, Ningbo Academy of Quarantine & Inspection Science and Technology, Ningbo 315000, Zhejiang, China

Corresponding:

*E-mail: DENG Simin,;
E-mail: CHENG Changyong,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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