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Research progress in ppGpp-mediated antibiotic stress response
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Xiao HU, Penshan SHEN, Jianping XU, Jiaqi YU, Jianhua YIN*
Acta Microbiologica Sinica | 2024, 64(3) : 687 - 700
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Acta Microbiologica Sinica | 2024, 64(3): 687-700
• Reviews •
Research progress in ppGpp-mediated antibiotic stress response
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Xiao HU, Penshan SHEN, Jianping XU, Jiaqi YU, Jianhua YIN*
Affiliations
  • College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China
Published: 2024-03-04 doi: 10.13343/j.cnki.wsxb.20230564
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Antibiotics are secondary metabolites produced by microorganisms during the stationary phase. They are widely used in the clinical treatment of bacterial infections because of their ability to kill bacteria or inhibit bacterial growth. In the long-term evolutionary process, bacteria have adopted several strategies to cope with the threats of antibiotics in the environment. In addition to the well-known antibiotic resistance, bacteria can develop tolerance and persistence to antibiotics, which seriously affects the clinical efficacy of antibiotics. Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (herein collectively referred to as ppGpp) are the alarmone signal molecules produced by bacteria in response to unfavorable environmental conditions such as nutritional starvation. ppGpp can regulate transcription globally and enable bacteria to survive in unfavorable conditions. An increasing number of studies have shown that ppGpp is closely related to antibiotic stress response. On this basis, this review summarizes the synthesis, hydrolysis, and mechanism of action of ppGpp in bacteria, with emphasis on the role of ppGpp in antibiotic stress response. This review aims to provide new ideas for the development of novel antibiotics.

ppGpp  /  stringent response  /  antibiotic resistance  /  antibiotic tolerance  /  antibiotic persistence  /  stress response
Xiao HU, Penshan SHEN, Jianping XU, Jiaqi YU, Jianhua YIN. Research progress in ppGpp-mediated antibiotic stress response[J]. Acta Microbiologica Sinica, 2024 , 64 (3) : 687 -700 . DOI: 10.13343/j.cnki.wsxb.20230564
Funding
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  • National Natural Science Foundation of China(32270044)
Appendix
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Year 2024 volume 64 Issue 3
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Article Info
doi: 10.13343/j.cnki.wsxb.20230564
  • Receive Date：2023-09-04
  • Online Date：2026-03-19
  • Published：2024-03-04
Article Data
Affiliations
History
  • Received：2023-09-04
  • Accepted：2023-12-11
Funding
National Natural Science Foundation of China(32270044)
Affiliations
    College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China

Corresponding:

*YIN Jianhua, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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