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Progress in experimental techniques for the discovery and target determination of pathogen sRNAs targeting hosts
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Yingrong XIN1, 2, Xinying DU2, Mingjuan YANG2, Hongbin SONG2, *, Ligui WANG2, *
Acta Microbiologica Sinica | 2024, 64(4) : 1019 - 1030
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Acta Microbiologica Sinica | 2024, 64(4): 1019-1030
• Reviews •
Progress in experimental techniques for the discovery and target determination of pathogen sRNAs targeting hosts
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Yingrong XIN1, 2, Xinying DU2, Mingjuan YANG2, Hongbin SONG2, *, Ligui WANG2, *
Affiliations
  • 1 College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
  • 2 The Chinese PLA Center for Disease Control and Prevention, Beijing 100071, China
Published: 2024-04-04 doi: 10.13343/j.cnki.wsxb.20230670
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People are exposed to environments containing various pathogens, which have multiple interactions with human cells or tissues. Pathogens can survive in the host environment by regulating pathogenic conditions such as virulence and invasiveness. At the same time, host cells resist the invasion of pathogens by mobilizing their own immune system. However, researchers mainly focus on the physiological functions of sRNAs in pathogens and have gained limited knowledge about the interactions between pathogens and hosts. How to use highly sensitive and high-resolution methods to study the interactions between pathogens and hosts have become a major challenge in the current research. By reviewing relevant studies, we summarize the commonly used techniques and experimental processes for studying the interactions between pathogens and hosts, aiming to improve the understanding about the mechanisms and principles of these experimental techniques and provide technical references for the research on interactions between pathogen sRNAs and host targets.

pathogen sRNA  /  host target  /  interaction  /  experimental technique
Yingrong XIN, Xinying DU, Mingjuan YANG, Hongbin SONG, Ligui WANG. Progress in experimental techniques for the discovery and target determination of pathogen sRNAs targeting hosts[J]. Acta Microbiologica Sinica, 2024 , 64 (4) : 1019 -1030 . DOI: 10.13343/j.cnki.wsxb.20230670
Funding
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  • National Key Research and Development Program of China(2022YFC2602304)
Appendix
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Year 2024 volume 64 Issue 4
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Article Info
doi: 10.13343/j.cnki.wsxb.20230670
  • Receive Date：2023-11-01
  • Online Date：2026-03-19
  • Published：2024-04-04
Article Data
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History
  • Received：2023-11-01
  • Accepted：2024-01-29
Funding
National Key Research and Development Program of China(2022YFC2602304)
Affiliations
    1 College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
    2 The Chinese PLA Center for Disease Control and Prevention, Beijing 100071, China

Corresponding:

*SONG Hongbin, E-mail:;
WANG Ligui, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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