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Research progress in synthesis and production technology of pyrroloquinoline quinone
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Dongfang LIU1, Jianzhong HUANG1, Yong TAO2, Xinwei YANG1, *, Chongrong KE1, 2, *
Acta Microbiologica Sinica | 2024, 64(4) : 999 - 1018
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Acta Microbiologica Sinica | 2024, 64(4): 999-1018
• Reviews •
Research progress in synthesis and production technology of pyrroloquinoline quinone
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Dongfang LIU1, Jianzhong HUANG1, Yong TAO2, Xinwei YANG1, *, Chongrong KE1, 2, *
Affiliations
  • 1 Engineering Research Center of Industrial Microbiology of the Ministry of Education, National and Local Joint Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, Fujian, China
  • 2 CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Published: 2024-04-04 doi: 10.13343/j.cnki.wsxb.20230660
Outline
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Pyrroloquinoline quinone (PQQ), the third oxidoreductase coenzyme discovered in the nature after nicotinamide and riboflavin, is ubiquitous in bacteria, fungi, plants, and animals. PQQ participates in a variety of life activities and has anti-inflammation, anti-oxidation, cell metabolism-enhancing, and cardioprotective activities, demonstrating broad application prospects in pharmaceuticals, agriculture, food and other fields. Therefore, the large-scale production of PQQ is the primary problem that needs to be solved at present. Microbial fermentation is a primary production method of PQQ. Deciphering the biosynthesis pathway and regulatory mechanism of PQQ is essential for the screening and breeding of strains with short production periods and high yields by metabolic engineering, which has been a hot topic in this field. This paper summarizes the synthesis pathways, strain screening and breeding, microbial production, and purification processes of PQQ, aiming to provide a reference for further research and application of PQQ.

pyrroloquinoline quinone  /  synthesis pathway  /  strain screening and breeding  /  metabolic regulation  /  isolation and purification
Dongfang LIU, Jianzhong HUANG, Yong TAO, Xinwei YANG, Chongrong KE. Research progress in synthesis and production technology of pyrroloquinoline quinone[J]. Acta Microbiologica Sinica, 2024 , 64 (4) : 999 -1018 . DOI: 10.13343/j.cnki.wsxb.20230660
Funding
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  • National Natural Science Foundation of China(22377012)
  • National Natural Science Foundation of China(21807011)
  • Natural Science Foundation General Program of Fujian Province(2021J01170)
  • Natural Science Foundation General Program of Fujian Province(2021J01172)
Appendix
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Year 2024 volume 64 Issue 4
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136
61
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Article Info
doi: 10.13343/j.cnki.wsxb.20230660
  • Receive Date：2023-10-27
  • Online Date：2026-03-19
  • Published：2024-04-04
Article Data
Affiliations
History
  • Received：2023-10-27
  • Accepted：2024-01-30
Funding
National Natural Science Foundation of China(22377012)
National Natural Science Foundation of China(21807011)
Natural Science Foundation General Program of Fujian Province(2021J01170)
Natural Science Foundation General Program of Fujian Province(2021J01172)
Affiliations
    1 Engineering Research Center of Industrial Microbiology of the Ministry of Education, National and Local Joint Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, Fujian, China
    2 CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

Corresponding:

*YANG Xinwei, E-mail:;
KE Chongrong, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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