Home Journals Articles Updates About
CN
image
收藏切换
Research progress in the role of IFN-β production induced byMycobacterium tuberculosis in immune regulation
收藏切换
PDF
Bei HUANG, Xiangmiao MENG, Jiangyao TIAN, Houhui SONG*, Yang YANG*
Acta Microbiologica Sinica | 2024, 64(2) : 331 - 343
Less
收藏切换
Acta Microbiologica Sinica | 2024, 64(2): 331-343
• Reviews •
Research progress in the role of IFN-β production induced byMycobacterium tuberculosis in immune regulation
Full
Bei HUANG, Xiangmiao MENG, Jiangyao TIAN, Houhui SONG*, Yang YANG*
Affiliations
  • China-Australia Joint Laboratory for Animal Health Big Data Analytics, Key Laboratory of Applied Technology on Green-eco-healthy Animal Husbandry of Zhejiang Province, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
Published: 2024-02-04 doi: 10.13343/j.cnki.wsxb.20230416
Outline
收藏切换

Mycobacterium tuberculosis (Mtb), the pathogen of tuberculosis (TB), threatens the health of millions of people worldwide. The pattern recognition receptors (PRRs) including DNA and RNA sensors on immune cells recognize the invaded Mtb to activate the innate immune system and induce the production of interferon-beta (IFN-β). IFN-β is a major effector cytokine in innate antiviral response, while its role in the host response to Mtb infection remains controversial. IFN-β induced by Mtb can promote bacterial growth and improve the bacterial survival in the host. However, IFN-β treatment before Mtb infection can protect the host from bacterial infection. Focusing on the PRR signaling pathways that can recognize Mtb and mediate the IFN-β production, this review expounds the role of IFN-β in mediating the regulation of immune function by Mtb, especially the mutual inhibitory effect between IFN-β and IL-1β, aiming to reveal the pathogenic mechanism of Mtb and facilitate future research and development of anti-TB drugs.

Mycobacterium tuberculosis  /  IFN-β  /  signaling pathway
Bei HUANG, Xiangmiao MENG, Jiangyao TIAN, Houhui SONG, Yang YANG. Research progress in the role of IFN-β production induced byMycobacterium tuberculosis in immune regulation[J]. Acta Microbiologica Sinica, 2024 , 64 (2) : 331 -343 . DOI: 10.13343/j.cnki.wsxb.20230416
Funding
Less
  • Zhejiang Provincial Natural Science Foundation(LTGD23C180001)
  • Fundamental Research Funds for Grant from Zhejiang A&F University(2022LFR067)
  • Fundamental Research Funds for the Provincial Universities of Zhejiang(2020YQ008)
  • National Natural Science Foundation of China(32272951)
Appendix
Less
Year 2024 volume 64 Issue 2
PDF
118
47
Cite this Article
BibTeX
Article Info
doi: 10.13343/j.cnki.wsxb.20230416
  • Receive Date：2023-06-14
  • Online Date：2026-03-18
  • Published：2024-02-04
Article Data
Affiliations
History
  • Received：2023-06-14
  • Accepted：2023-08-15
Funding
Zhejiang Provincial Natural Science Foundation(LTGD23C180001)
Fundamental Research Funds for Grant from Zhejiang A&F University(2022LFR067)
Fundamental Research Funds for the Provincial Universities of Zhejiang(2020YQ008)
National Natural Science Foundation of China(32272951)
Affiliations
    China-Australia Joint Laboratory for Animal Health Big Data Analytics, Key Laboratory of Applied Technology on Green-eco-healthy Animal Husbandry of Zhejiang Province, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China

Corresponding:

*E-mail: SONG Houhui,;
E-mail: YANG Yang,
References
Share
https://castjournals.cast.org.cn/joweb/wswxb/EN/10.13343/j.cnki.wsxb.20230416
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House