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Advances in functional proteins of type VI secretion system ofAcinetobacter baumannii
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Hairong WANG1, 2, Nianzhi NING2, Hui WANG1, 2, *
Acta Microbiologica Sinica | 2024, 64(2) : 391 - 407
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Acta Microbiologica Sinica | 2024, 64(2): 391-407
• Reviews •
Advances in functional proteins of type VI secretion system ofAcinetobacter baumannii
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Hairong WANG1, 2, Nianzhi NING2, Hui WANG1, 2, *
Affiliations
  • 1 School of Public Health, Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang, China
  • 2 State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100071, China
Published: 2024-02-04 doi: 10.13343/j.cnki.wsxb.20230513
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The type VI secretion system (T6SS) as a dynamic multi-protein complex has a clear division of labor among its components, transporting effector proteins to compete for bacterial growth. Studies have shown that T6SS mediates the competitiveness ofAcinetobacter baumannii in the microbial community and affects the drug resistance evolution and invasion in the host. Particularly, the valine-glycine repeat protein G (VgrG), the proline-alanine-alanine-arginine (PAAR), the hemolysin-coregulated protein (Hcp), and the effector-immunity (E-I) pair play a key role. Although T6SS has been extensively studied, there are few articles about its clinical application prospects, as this poses challenges to the identification, characterization, transport mechanism revealing, and other basic research on their functional proteins. We reviewed the research progress in the distribution, functional protein characteristics, and transport mechanism of T6SS inA.baumannii and provided evidence for its application based on the application cases of T6SS. This review aims to promote the research on the genes and functions of T6SS inA.baumannii and provide new targets and ideas for developing new anti-infective vaccines, screening suitable inhibitors, and producing engineered drug delivery tools.

Acinetobacter baumannii  /  type VI secretion system  /  valine-glycine repeat protein G  /  proline-alanine-alanine-arginine  /  hemolysin-coregulated protein  /  effector-immunity pair
Hairong WANG, Nianzhi NING, Hui WANG. Advances in functional proteins of type VI secretion system ofAcinetobacter baumannii[J]. Acta Microbiologica Sinica, 2024 , 64 (2) : 391 -407 . DOI: 10.13343/j.cnki.wsxb.20230513
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  • Independent Research Project of State Key Laboratory of Pathogen and Biosecurity(SKLPBS2228)
Appendix
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Year 2024 volume 64 Issue 2
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Article Info
doi: 10.13343/j.cnki.wsxb.20230513
  • Receive Date：2023-08-06
  • Online Date：2026-03-18
  • Published：2024-02-04
Article Data
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History
  • Received：2023-08-06
  • Accepted：2023-09-18
Funding
Independent Research Project of State Key Laboratory of Pathogen and Biosecurity(SKLPBS2228)
Affiliations
    1 School of Public Health, Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang, China
    2 State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100071, China

Corresponding:

*WANG Hui, Tel/Fax: +86-10-66948532, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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