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SapB-like peptides promote morphological differentiation ofStreptomyces
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Hongjun SHAN, Junbo WANG, Baixin LIN, Kehui WANG, Zixin DENG, Delin YOU, Lingxin KONG*
Acta Microbiologica Sinica | 2024, 64(1) : 268 - 282
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Acta Microbiologica Sinica | 2024, 64(1): 268-282
• Research Articles •
SapB-like peptides promote morphological differentiation ofStreptomyces
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Hongjun SHAN, Junbo WANG, Baixin LIN, Kehui WANG, Zixin DENG, Delin YOU, Lingxin KONG*
Affiliations
  • State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China
Published: 2024-01-04 doi: 10.13343/j.cnki.wsxb.20230421
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[Objective] Streptomyces is a genus of Gram-positive aerobic bacteria characterized by complex morphological differentiation and potent secondary metabolite-producing ability. SapB, a class Ⅲ lanthipeptide, promotes the morphological differentiation ofStreptomyces coelicolor, which suggests that SapB-like peptides might be developed as targets for engineering of morphological differentiation. In this study, we characterized the effects of SapB-like peptides on the morphological differentiation of multipleStreptomyces species, aiming to provide a theoretical basis for the engineering of these peptides.[Methods] Bioinformatics tools were used to analyze the gene clusters for the synthesis of SapB-like peptides in the genomes ofStreptomyces spp.. The plasmids for heterologous expression were constructed and introduced intoStreptomyces spp. through conjugation. The colony and mycelial morphology were compared to reveal the effects of these peptides on the morphological differentiation ofStreptomyces.[Results] SapB-like peptides promoted the differentiation ofStreptomyces from vegetative to aerial mycelia. Specifically, they increased the aerial mycelia and accelerated the differentiation, thus shortening the morphological differentiation cycle.[Conclusion] SapB-like peptides can help shorten the morphological differentiation cycle ofStreptomyces, demonstrating the potential for the morphological differentiation engineering ofStreptomyces.

Streptomyces  /  morphological differentiation  /  aerial mycelium  /  lanthipeptide  /  SapB
Hongjun SHAN, Junbo WANG, Baixin LIN, Kehui WANG, Zixin DENG, Delin YOU, Lingxin KONG. SapB-like peptides promote morphological differentiation ofStreptomyces[J]. Acta Microbiologica Sinica, 2024 , 64 (1) : 268 -282 . DOI: 10.13343/j.cnki.wsxb.20230421
Funding
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  • National Natural Science Foundation of China(32170077)
  • National Natural Science Foundation of China(32170075)
  • Start-up Fund for Young Faculty at Shanghai Jiao Tong University(21X010500720)
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Year 2024 volume 64 Issue 1
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Article Info
doi: 10.13343/j.cnki.wsxb.20230421
  • Receive Date：2023-06-16
  • Online Date：2026-03-18
  • Published：2024-01-04
Article Data
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History
  • Received：2023-06-16
  • Accepted：2023-08-17
Funding
National Natural Science Foundation of China(32170077)
National Natural Science Foundation of China(32170075)
Start-up Fund for Young Faculty at Shanghai Jiao Tong University(21X010500720)
Affiliations
    State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China

Corresponding:

*KONG Lingxin, Tel: +86-21-62932943, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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