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Advances in the regulatory effects of ubiquitination on RLRs signaling pathways
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Rongqian MO1, 2, Hongshan LI1, 2, Dianyu LI1, 2, Xiangrong LI1, 2, *, Ruofei FENG1, 2, *
Acta Microbiologica Sinica | 2024, 64(1) : 42 - 60
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Acta Microbiologica Sinica | 2024, 64(1): 42-60
• Reviews •
Advances in the regulatory effects of ubiquitination on RLRs signaling pathways
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Rongqian MO1, 2, Hongshan LI1, 2, Dianyu LI1, 2, Xiangrong LI1, 2, *, Ruofei FENG1, 2, *
Affiliations
  • 1 Key Laboratory of Biotechnology and Bioengineering of National Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, Gansu, China
  • 2 College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, Gansu, China
Published: 2024-01-04 doi: 10.13343/j.cnki.wsxb.20230400
Outline
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Retinoid acid-inducible gene-I-like receptor (RLR) signaling pathways, the immune signaling pathways in response to infections, play a regulatory role in the production of pro-inflammatory cytokines, chemokines, and type Ⅰ interferons. Ubiquitination as one of the post-translational modifications refers to the process of ubiquitin binding to different amino acid sites on the target proteins, which regulates the fates of proteins. For example, it initiates the proteasome pathway to degrade the target protein or activating the protein transport. The ubiquitination of RLR signaling pathways is a way of regulating multiple effectors and one of the classical pathways through which viruses induce major diseases in animals, autoimmune diseases, and chronic inflammation. This paper introduces the typical structural features and the ubiquitination types of key effectors in the RLR signaling pathways. Furthermore, it expounds the roles of ubiquitination in the regulation of key molecules in the RLR signaling pathways, aiming to provide a reference for the intervention or treatment of related diseases.

retinoid acid-inducible gene-I-like receptors (RLRs)  /  ubiquitination  /  retinoic-acid-inducible gene I (RIG-I)  /  melanoma differentiation-associated antigen 5 (MDA5)  /  laboratory of genetics and physiology 2 (LGP2)
Rongqian MO, Hongshan LI, Dianyu LI, Xiangrong LI, Ruofei FENG. Advances in the regulatory effects of ubiquitination on RLRs signaling pathways[J]. Acta Microbiologica Sinica, 2024 , 64 (1) : 42 -60 . DOI: 10.13343/j.cnki.wsxb.20230400
Funding
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  • Fundamental Research Funds for the Central Universities of Northwest Minzu University(31920230163)
  • Fundamental Research Funds for the Central Universities of Northwest Minzu University(31920230162)
  • National Natural Science Foundation of China(32260037)
  • Ministry of Science and Technology "High-end Foreign Experts Introduction Program"(G2022187005L)
Appendix
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Year 2024 volume 64 Issue 1
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151
68
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Article Info
doi: 10.13343/j.cnki.wsxb.20230400
  • Receive Date：2023-06-07
  • Online Date：2026-03-18
  • Published：2024-01-04
Article Data
Affiliations
History
  • Received：2023-06-07
  • Accepted：2023-10-07
Funding
Fundamental Research Funds for the Central Universities of Northwest Minzu University(31920230163)
Fundamental Research Funds for the Central Universities of Northwest Minzu University(31920230162)
National Natural Science Foundation of China(32260037)
Ministry of Science and Technology "High-end Foreign Experts Introduction Program"(G2022187005L)
Affiliations
    1 Key Laboratory of Biotechnology and Bioengineering of National Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, Gansu, China
    2 College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, Gansu, China

Corresponding:

*E-mail: FENG Ruofei,;
E-mail: LI Xiangrong,
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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