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Review of bacteriophage therapy forKlebsiella pneumoniae infection
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Jiaqi ZHONG1, Yufei ZHOU1, Yulin XU1, Siye GONG1, Zhuoyang ZHANG2, *
Acta Microbiologica Sinica | 2024, 64(1) : 61 - 75
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Acta Microbiologica Sinica | 2024, 64(1): 61-75
• Reviews •
Review of bacteriophage therapy forKlebsiella pneumoniae infection
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Jiaqi ZHONG1, Yufei ZHOU1, Yulin XU1, Siye GONG1, Zhuoyang ZHANG2, *
Affiliations
  • 1 School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
  • 2 Experimental Teaching Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
Published: 2024-01-04 doi: 10.13343/j.cnki.wsxb.20230401
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With the evolution of bacteria and the overuse of certain antibiotics, drug-resistant bacterial infections have emerged as a major public health challenge in the 21st century.Klebsiella pneumoniae, in particular, has aroused wide concern due to its drug-resistant nature. Bacteriophages have demonstrated the potential and advantages in treating bacterial infections caused by drug-resistant strains, while there are no clinical guidelines for phage therapy. Notably, even though a few successful cases of bacteriophage therapy have been documented in the treatment ofK.pneumoniae infections, bacteriophages are used in combination with antibiotics in most cases and the role bacteriophages play remains unclear. This article provides an overview of bacteriophage therapies forK.pneumoniae infections, including their characteristics and the factors influencing their efficacy. We compiled and analyzed data from available studies, with the intention of offering valuable insights for the application of bacteriophage therapy in combatingK.pneumoniae and other drug-resistant bacteria.

Klebsiella pneumoniae  /  drug-resistant bacteria  /  bacteriophage therapy
Jiaqi ZHONG, Yufei ZHOU, Yulin XU, Siye GONG, Zhuoyang ZHANG. Review of bacteriophage therapy forKlebsiella pneumoniae infection[J]. Acta Microbiologica Sinica, 2024 , 64 (1) : 61 -75 . DOI: 10.13343/j.cnki.wsxb.20230401
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Article Info
doi: 10.13343/j.cnki.wsxb.20230401
  • Receive Date：2023-06-08
  • Online Date：2026-03-18
  • Published：2024-01-04
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History
  • Received：2023-06-08
  • Accepted：2023-09-11
Affiliations
    1 School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
    2 Experimental Teaching Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Corresponding:

*ZHANG Zhuoyang, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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