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Advances in synthesis of unsaturated fatty acids in bacteria
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Yonghong YU1, Jianrong MA1, *, Yuanyin ZHANG2, Mingfeng YAN2, Wenbin ZHANG2
Acta Microbiologica Sinica | 2024, 64(1) : 14 - 29
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Acta Microbiologica Sinica | 2024, 64(1): 14-29
• Reviews •
Advances in synthesis of unsaturated fatty acids in bacteria
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Yonghong YU1, Jianrong MA1, *, Yuanyin ZHANG2, Mingfeng YAN2, Wenbin ZHANG2
Affiliations
  • 1 Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong, China
  • 2 Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, Guangdong, China
Published: 2024-01-04 doi: 10.13343/j.cnki.wsxb.20230379
Outline
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Fatty acids are not only the components of cell membrane but also the raw materials for the synthesis of bioactive molecules. Unsaturated fatty acids (UFAs) with low phase-transition temperatures are essential molecules for bacteria to regulate cell membrane fluidity. Therefore, the synthetic pathways of UFAs are key targets for the screening of antibacterial agents. Bacteria can adopt the anaerobic pathway to synthesize UFAs. For example,Escherichia coli, a model organism, synthesizes UFAsvia the classic FabA-FabB pathway. However, the anaerobic pathways for the synthesis of UFAs vary in different bacteria, and the catalytic enzymes are also different. Bacteria can synthesize UFAsvia aerobic pathways, in which fatty acid desaturase directly converts saturated fatty acids (SFAs) into UFAs. Different desaturases introduce double bond to form UFAs with different structures, which play roles in stress responses, pathogenicity and other aspects. Other enzymes involved in the synthesis of fatty acids can also participate in the synthesis of UFAs or regulation of different UFAs. Some bacteria can use monooxygenase to convert capryl-ACP (acyl carrier protein) in the fatty acid synthesis pathway intocis-3-decenyl ACP to synthesize UFAs. We comprehensively reviewed the research progress in the synthesis of UFAs in bacteria, aiming to provide theoretical support for deciphering the mechanism of bacterial synthesis of UFAs and developing the targeted antibacterial drugs.

fatty acid synthesis  /  unsaturated fatty acids (UFAs)  /  anaerobic pathway  /  aerobic pathway
Yonghong YU, Jianrong MA, Yuanyin ZHANG, Mingfeng YAN, Wenbin ZHANG. Advances in synthesis of unsaturated fatty acids in bacteria[J]. Acta Microbiologica Sinica, 2024 , 64 (1) : 14 -29 . DOI: 10.13343/j.cnki.wsxb.20230379
Funding
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  • Characteristic Innovation Project of Colleges and Universities in Guangdong Province(2022KTSCX271)
  • Medical Science and Technology of Guangdong Province(A2023056)
  • Science Foundation of Guangdong Food and Drug Vocational College(2022ZR06)
  • Science Foundation of Guangdong Food and Drug Vocational College(2021ZR15)
Appendix
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Year 2024 volume 64 Issue 1
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142
66
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Article Info
doi: 10.13343/j.cnki.wsxb.20230379
  • Receive Date：2023-05-31
  • Online Date：2026-03-15
  • Published：2024-01-04
Article Data
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History
  • Received：2023-05-31
  • Accepted：2023-08-14
Funding
Characteristic Innovation Project of Colleges and Universities in Guangdong Province(2022KTSCX271)
Medical Science and Technology of Guangdong Province(A2023056)
Science Foundation of Guangdong Food and Drug Vocational College(2022ZR06)
Science Foundation of Guangdong Food and Drug Vocational College(2021ZR15)
Affiliations
    1 Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong, China
    2 Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, Guangdong, China

Corresponding:

*MA Jianrong, Tel: +86-20-29164616, Fax: +86-20-37216531, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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