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The Tad pilus secretin CpaC is associated with motility, biofilm formation, and pathogenicity of Vibrio parahaemolyticus
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Xuerui BAI1, Rong GUO2, Shuqi LU2, Bingbing FAN2, Quan ZHANG2, Weihuan FANG3, Wei JIANG2, *
Acta Microbiologica Sinica | 2026, 66(3) : 1278 - 1293
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Acta Microbiologica Sinica | 2026, 66(3): 1278-1293
• Research Article •
The Tad pilus secretin CpaC is associated with motility, biofilm formation, and pathogenicity of Vibrio parahaemolyticus
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Xuerui BAI1, Rong GUO2, Shuqi LU2, Bingbing FAN2, Quan ZHANG2, Weihuan FANG3, Wei JIANG2, *
Affiliations
  • 1.Department of Animal Science and Technology, Shanghai Vocational College of Agriculture and Forestry, Shanghai, China
  • 2.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
  • 3.College of Animal Science and Technology, Zhejiang A&F University, Lin’an, Zhejiang, China
Published: 2026-03-04 doi: 10.13343/j.cnki.wsxb.20250783
Outline
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Objective Tad pili are widely distributed in Gram-negative bacteria and are associated with the virulence of various pathogens. However, the studies about the Tad pili in Vibrio parahaemolyticus remain limited. This study aimed to elucidate the role of the Tad pilus secretin CpaC (VP2419) in the biological functions of V. parahaemolyticus. Methods The cpaC-deleted mutant (ΔcpaC) and complemented strain (CΔcpaC) were constructed from the wild-type (WT) strain (SH112) of V. parahaemolyticus. The strains were compared in terms of biofilm formation, competitiveness, swarming and swimming motility, cell adhesion, cytotoxicity, as well as virulence, tissue colonization, and pathology in mice. Results Regarding environmental adaptation, compared with the WT strain, ΔcpaC exhibited significantly decreased competitiveness, motility, and biofilm formation. In terms of pathogenicity, ΔcpaC demonstrated significantly reduced cell adhesion, cytotoxicity, as well as attenuated virulence, tissue colonization, and pathological damage in mice, compared with the WT strain. Conclusion As the Tad pilus secretin in V. parahaemolyticus, CpaC participates in multiple functions related to environmental adaptation and pathogenicity, including competitiveness, biofilm formation, motility, cell adhesion, cytotoxicity, and tissue colonization. These findings provide important insights for a deeper understanding of the biological functions of Tad pili.

Vibrio parahaemolyticus  /  Tad pilus  /  biofilm  /  motility  /  pathogenicity
Xuerui BAI, Rong GUO, Shuqi LU, Bingbing FAN, Quan ZHANG, Weihuan FANG, Wei JIANG. The Tad pilus secretin CpaC is associated with motility, biofilm formation, and pathogenicity of Vibrio parahaemolyticus[J]. Acta Microbiologica Sinica, 2026 , 66 (3) : 1278 -1293 . DOI: 10.13343/j.cnki.wsxb.20250783
Funding
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  • National Natural Science Foundation of China(32473039)
  • Research Project of Shanghai Vocational College of Agriculture and Forestry(KY6-0000-25-02)
Appendix
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Year 2026 volume 66 Issue 3
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136
62
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Article Info
doi: 10.13343/j.cnki.wsxb.20250783
  • Receive Date：2025-10-19
  • Online Date：2026-03-12
  • Published：2026-03-04
Article Data
Affiliations
History
  • Received：2025-10-19
  • Accepted：2025-12-18
Funding
National Natural Science Foundation of China(32473039)
Research Project of Shanghai Vocational College of Agriculture and Forestry(KY6-0000-25-02)
Affiliations
    1.Department of Animal Science and Technology, Shanghai Vocational College of Agriculture and Forestry, Shanghai, China
    2.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
    3.College of Animal Science and Technology, Zhejiang A&F University, Lin’an, Zhejiang, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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