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Research progress on the impact of heat shock protein family A member 8 on virus infection of host cells
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Siyuan LI1, Zhentao ZHANG2, Yanlong LIN3, Fei WANG4, Xiaobo HE5, Jianshe YANG1, Weike LI1, *, Jiansheng ZHOU2, *
Acta Microbiologica Sinica | 2026, 66(3) : 990 - 1006
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Acta Microbiologica Sinica | 2026, 66(3): 990-1006
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Research progress on the impact of heat shock protein family A member 8 on virus infection of host cells
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Siyuan LI1, Zhentao ZHANG2, Yanlong LIN3, Fei WANG4, Xiaobo HE5, Jianshe YANG1, Weike LI1, *, Jiansheng ZHOU2, *
Affiliations
  • 1.State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
  • 2.Shandong Animal Health Technology Center, Jinan, Shandong, China
  • 3.Lanzhou Institute of Biological Products Co. , Ltd. , Lanzhou, Gansu, China
  • 4.Qingzhou Animal Husbandry Development Center, Qingzhou, Shandong, China
  • 5.Shandong Zhuohua Biotechnology Co. , Ltd. , Liaocheng, Shandong, China
Published: 2026-03-04 doi: 10.13343/j.cnki.wsxb.20250714
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Heat shock protein family A member 8 (HSPA8) is a widely distributed molecular chaperone in cells. HSPA8 is involved in multiple cellular physiological processes, mainly including the correct folding and transport of proteins, stress responses, presentation of antigenic proteins, mediation of autophagy, and immune regulation. It is also crucial for maintaining the homeostasis of the intracellular environment. In addition, HSPA8 plays a key role in multiple processes of virus infections. This paper reviewed the important roles and molecular mechanisms of HSPA8 in processes such as virus adhesion, formation of virus glycoprotein-receptor complexes, internalization, uncoating, genome replication, assembly, and regulation of host metabolism and immune responses, with the hope of laying a foundation for the subsequent development of drugs targeting HSPA8 for the treatment of virus infections.

HSPA8  /  virus infection  /  regulatory mechanism
Siyuan LI, Zhentao ZHANG, Yanlong LIN, Fei WANG, Xiaobo HE, Jianshe YANG, Weike LI, Jiansheng ZHOU. Research progress on the impact of heat shock protein family A member 8 on virus infection of host cells[J]. Acta Microbiologica Sinica, 2026 , 66 (3) : 990 -1006 . DOI: 10.13343/j.cnki.wsxb.20250714
Funding
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  • Major Science and Technology Special Project of Gansu Province(22ZD6NA001)
Appendix
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Year 2026 volume 66 Issue 3
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Article Info
doi: 10.13343/j.cnki.wsxb.20250714
  • Receive Date：2025-09-19
  • Online Date：2026-03-12
  • Published：2026-03-04
Article Data
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History
  • Received：2025-09-19
  • Accepted：2025-12-02
Funding
Major Science and Technology Special Project of Gansu Province(22ZD6NA001)
Affiliations
    1.State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
    2.Shandong Animal Health Technology Center, Jinan, Shandong, China
    3.Lanzhou Institute of Biological Products Co. , Ltd. , Lanzhou, Gansu, China
    4.Qingzhou Animal Husbandry Development Center, Qingzhou, Shandong, China
    5.Shandong Zhuohua Biotechnology Co. , Ltd. , Liaocheng, Shandong, China

Corresponding:

*E-mail: LI Weike,
ZHOU Jiansheng,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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