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Staphylococcus aureus, a common foodborne pathogen causing hospital-acquired infection, poses a grave threat to public health and safety, resulting in a substantial economic burden on the society. As a conditionally essential amino acid, arginine exhibits a dual role in the infection of S. aureus and the immune response of the host. On the one hand, arginine synthesis and catabolism are involved in pathogenic processes such as the biofilm formation and antibiotic resistance of S. aureus. On the other hand, arginine metabolites play an important role in anti-infective immunity, tissue repair, and wound healing through the modulation of macrophage polarization, immune modulation, metabolic reprogramming, and signaling. Recent studies suggest that arginine metabolism constitutes a regulatory hub for S. aureus-macrophage interactions, and its metabolic balance affects the progression and regression of infection and anti-infection. Consequently, targeting the arginine metabolic pathway to impede S. aureus infection by regulating host-pathogen metabolic interactions has emerged as a novel anti-S. aureus therapeutic strategy with significant translational medical relevance. In this review, we focus on the metabolic utilization of arginine to describe how S. aureus and macrophages exert their respective biological functions by competing for the utilization of arginine. In addition, we summarize the changes of arginine levels in macrophages during S. aureus infection to explore the feasible research directions and challenges of regulating arginine metabolism as a potential antimicrobial strategy in the future.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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