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Mechanism of quercetin-induced apoptosis in Trichosporon asahii
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Haochen GUO1, 2, Lingzhi XU1, 2, Xin YANG2, Zhikuan XIA1, 2, *, Rongya YANG1, 2, *
Acta Microbiologica Sinica | 2026, 66(3) : 1394 - 1411
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Acta Microbiologica Sinica | 2026, 66(3): 1394-1411
• Research Article •
Mechanism of quercetin-induced apoptosis in Trichosporon asahii
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Haochen GUO1, 2, Lingzhi XU1, 2, Xin YANG2, Zhikuan XIA1, 2, *, Rongya YANG1, 2, *
Affiliations
  • 1.The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China
  • 2.Department of Dermatology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China
Published: 2026-03-04 doi: 10.13343/j.cnki.wsxb.20250957
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Objective To evaluate the in vitro antifungal activity of quercetin against Trichosporon asahii and investigate its molecular mechanism of inducing fungal apoptosis. Methods According to the CLSI M27-A3 protocol, the inhibitory effects of quercetin on planktonic cells and biofilm formation of nine T. asahii strains were determined. On this basis, changes in intracellular reactive oxygen species (ROS) level, mitochondrial membrane potential (MMP), and cysteinyl aspartate-specific proteinase 3 (Caspase-3) activity were measured following quercetin intervention. Subsequently, transcriptome sequencing was utilized to verify and analyze the differentially expressed genes. Results The minimum inhibitory concentrations (MICs) of quercetin against T. asahii ranged from 8 to 32 μg/mL, and quercetin effectively inhibited biofilm formation. Cellular experiments indicated that quercetin triggered apoptosis by inducing ROS accumulation, reducing MMP, and activating Caspase-3. Transcriptomic data further confirmed the aforementioned mechanisms at the gene expression level. Conclusion Quercetin exerts antifungal activity against T. asahii primarily by inducing oxidative stress-mediated apoptosis.

quercetin  /  antifungal  /  Trichosporon asahii
Haochen GUO, Lingzhi XU, Xin YANG, Zhikuan XIA, Rongya YANG. Mechanism of quercetin-induced apoptosis in Trichosporon asahii[J]. Acta Microbiologica Sinica, 2026 , 66 (3) : 1394 -1411 . DOI: 10.13343/j.cnki.wsxb.20250957
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  • National Natural Science Foundation of China(82373494)
Appendix
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Year 2026 volume 66 Issue 3
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Article Info
doi: 10.13343/j.cnki.wsxb.20250957
  • Receive Date：2025-12-23
  • Online Date：2026-03-12
  • Published：2026-03-04
Article Data
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History
  • Received：2025-12-23
  • Accepted：2026-01-15
Funding
National Natural Science Foundation of China(82373494)
Affiliations
    1.The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China
    2.Department of Dermatology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China

Corresponding:

*E-mail: XIA Zhikuan,
YANG Rongya,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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