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A potential anti-Staphylococcusaureus target: SaeRS two-component regulatory system
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Yuhuang WU1, 2, Xian YUE1, 2, Qingyong ZHANG3, Lili ZOU1, 2, *, Wei CHEN1, 2, *
Acta Microbiologica Sinica | 2025, 65(3) : 939 - 955
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Acta Microbiologica Sinica | 2025, 65(3): 939-955
• Review •
A potential anti-Staphylococcusaureus target: SaeRS two-component regulatory system
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Yuhuang WU1, 2, Xian YUE1, 2, Qingyong ZHANG3, Lili ZOU1, 2, *, Wei CHEN1, 2, *
Affiliations
  • 1 Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang, Hubei, China
  • 2 Yichang Key Laboratory of Infection and Inflammation, College of Basic Medical Sciences, China Three Gorges University, Yichang, Hubei, China
  • 3 The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China
Published: 2025-03-04 doi: 10.13343/j.cnki.wsxb.20240608
Outline
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The SaeRS system has been extensively and intensively studied for its involvement in the regulation of virulence factor expression and biofilm formation in the Gram-positive pathogen Staphylococcusaureus, mediating severe pathogenicity. The activation of the system depends on the recognition of external signals by the sensor histidine kinase SaeS and the phosphorylation status of the response regulator SaeR. With the help of auxiliary proteins SaeP and SaeQ, S. aureus is prompted to express a variety of virulence factors, coordinate its biofilm formation, and even evade the host immune response. In addition, other regulatory systems and modulators of S. aureus can synergize with the SaeRS system to participate in the regulation of virulence factor expression, enhancing bacterial pathogenicity. This paper reviews the SaeRS system and its interactions with other regulatory systems and factors to regulate the expression of virulence factors and biofilm formation. It summarizes targeted drugs against the SaeRS system and analyzes specific examples of anti-SaeRS system drugs to provide clues for the screening and design of new targeted drugs. This review is expected to provide a theoretical basis for the research on the specific regulatory mechanisms of the SaeRS system and the treatment of S. aureus-associated infections.

Staphylococcusaureus  /  SaeRS two-component system  /  virulence factor  /  biofilm  /  antibacterial target
Yuhuang WU, Xian YUE, Qingyong ZHANG, Lili ZOU, Wei CHEN. A potential anti-Staphylococcusaureus target: SaeRS two-component regulatory system[J]. Acta Microbiologica Sinica, 2025 , 65 (3) : 939 -955 . DOI: 10.13343/j.cnki.wsxb.20240608
Funding
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  • Innovation and Development Joint Fund of Natural Science Foundation of Hubei Province(2024AFD132)
  • Innovation and Development Joint Fund of Natural Science Foundation of Hubei Province(2024AFD145)
  • Yichang Medical and Health Research Project(A24-2-061)
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Year 2025 volume 65 Issue 3
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Article Info
doi: 10.13343/j.cnki.wsxb.20240608
  • Receive Date：2024-10-04
  • Online Date：2026-02-10
  • Published：2025-03-04
Article Data
Affiliations
History
  • Received：2024-10-04
  • Accepted：2024-11-06
Funding
Innovation and Development Joint Fund of Natural Science Foundation of Hubei Province(2024AFD132)
Innovation and Development Joint Fund of Natural Science Foundation of Hubei Province(2024AFD145)
Yichang Medical and Health Research Project(A24-2-061)
Affiliations
    1 Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang, Hubei, China
    2 Yichang Key Laboratory of Infection and Inflammation, College of Basic Medical Sciences, China Three Gorges University, Yichang, Hubei, China
    3 The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China

Corresponding:

*E-mail: CHEN Wei:
ZOU Lili,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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