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Whole-cell microbial biosensors for heavy metals: design principles, optimization strategies, and monitoring applications
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Mingyue WANG1, 2, Meiying XU2, Min JIU1, *, Xingjuan CHEN2, *
Acta Microbiologica Sinica | 2025, 65(3) : 1033 - 1052
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Acta Microbiologica Sinica | 2025, 65(3): 1033-1052
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Whole-cell microbial biosensors for heavy metals: design principles, optimization strategies, and monitoring applications
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Mingyue WANG1, 2, Meiying XU2, Min JIU1, *, Xingjuan CHEN2, *
Affiliations
  • 1 College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan, China
  • 2 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
Published: 2025-03-04 doi: 10.13343/j.cnki.wsxb.20240619
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Heavy metal pollution has attracted increasing attention because of its toxicity, environmental persistence, bioaccumulation, and potential contribution to antibiotic resistance. The accurate, rapid, efficient, and sensitive detection of heavy metals in the environment is of great significance for environmental protection and human health. A whole-cell microbial biosensor (WCMB), integrating a biorecognition module and a signal processing module, provides a new strategy for heavy metal monitoring. Great progress has been achieved in the transcription factor-based WCMBs for the monitoring of heavy metals in recent years. This paper introduced the basic composition and design principles of WCMBs, summarized the construction and application of WCMBs for heavy metal detection that were developed in recent years, analyzed the optimization strategies of WCMBs by synthetic biology, and finally prospected the future research directions of WCMBs. This paper is expected to be an important reference for the effective prevention and control of heavy metal pollution in the environment.

heavy metals  /  whole-cell microbial biosensor  /  design  /  optimization  /  application
Mingyue WANG, Meiying XU, Min JIU, Xingjuan CHEN. Whole-cell microbial biosensors for heavy metals: design principles, optimization strategies, and monitoring applications[J]. Acta Microbiologica Sinica, 2025 , 65 (3) : 1033 -1052 . DOI: 10.13343/j.cnki.wsxb.20240619
Funding
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  • Key Research and Development Program of Guangdong Province(2023B0202040001)
  • GDAS Project of Science and Technology Development(2022GDASZH-2022010101)
Appendix
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Year 2025 volume 65 Issue 3
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163
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Article Info
doi: 10.13343/j.cnki.wsxb.20240619
  • Receive Date：2024-10-10
  • Online Date：2026-02-10
  • Published：2025-03-04
Article Data
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History
  • Received：2024-10-10
  • Accepted：2024-11-25
Funding
Key Research and Development Program of Guangdong Province(2023B0202040001)
GDAS Project of Science and Technology Development(2022GDASZH-2022010101)
Affiliations
    1 College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan, China
    2 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China

Corresponding:

*E-mail: CHEN Xingjuan,
JIU Min,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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