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Research progress in jumbo phages
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Bo HE1, Xinyu JIANG1, Jianglin LIAO1, 2, Shuguang LU1, *, Shuai LE1, *
Acta Microbiologica Sinica | 2025, 65(3) : 1017 - 1032
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Acta Microbiologica Sinica | 2025, 65(3): 1017-1032
• Review •
Research progress in jumbo phages
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Bo HE1, Xinyu JIANG1, Jianglin LIAO1, 2, Shuguang LU1, *, Shuai LE1, *
Affiliations
  • 1 Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China
  • 2 Department of Cardiovascular Medicine, the Southwest Hospital of Army Medical University, Chongqing, China
Published: 2025-03-04 doi: 10.13343/j.cnki.wsxb.20240605
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In the post-antibiotic era, phage therapy becomes a candidate for treating drug-resistant bacteria. Phages are diverse, and jumbo phages are a class of phages with genomes longer than 200 kb. Their large genomes carry abundant functional genes with scattered distribution. Jumbo phages have a variety of unique biological characteristics, such as oversized phage particles, unique replication cycles, and unique structures such as the nucleus-like compartment, the “inner body”, and the long-wavy curly tail fiber. This paper reviews the research progress in jumbo phages, focusing on their biological characteristics, genomes, evolution, and special replication mechanisms and structures. Furthermore, this review explores the application potential of jumbo phages in the treatment of drug-resistant bacterial infection, environmental management, aquaculture, and biocontrol, aiming to provide reference and implications for the research and application of jumbo phages.

jumbo phages  /  genome and evolution  /  nucleus-like compartment  /  phage therapy  /  application progress
Bo HE, Xinyu JIANG, Jianglin LIAO, Shuguang LU, Shuai LE. Research progress in jumbo phages[J]. Acta Microbiologica Sinica, 2025 , 65 (3) : 1017 -1032 . DOI: 10.13343/j.cnki.wsxb.20240605
Funding
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  • National Key Research and Development Program of China(2021YFA0911200)
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Year 2025 volume 65 Issue 3
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Article Info
doi: 10.13343/j.cnki.wsxb.20240605
  • Receive Date：2024-10-01
  • Online Date：2026-02-10
  • Published：2025-03-04
Article Data
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History
  • Received：2024-10-01
  • Accepted：2024-11-01
Funding
National Key Research and Development Program of China(2021YFA0911200)
Affiliations
    1 Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China
    2 Department of Cardiovascular Medicine, the Southwest Hospital of Army Medical University, Chongqing, China

Corresponding:

*E-mail: LU Shuguang:
LE Shuai:
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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