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Research progress in shikimic acid biosynthesis
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Huanghui XIA, Shumei CUI, Jianzhong HUANG*
Acta Microbiologica Sinica | 2025, 65(3) : 916 - 938
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Acta Microbiologica Sinica | 2025, 65(3): 916-938
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Research progress in shikimic acid biosynthesis
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Huanghui XIA, Shumei CUI, Jianzhong HUANG*
Affiliations
  • Engineering Research Center of Industrial Microbiology, Ministry of Education, National and Local United Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China
Published: 2025-03-04 doi: 10.13343/j.cnki.wsxb.20240640
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Shikimic acid (SA) is an important natural compound with many biological activities, including antiviral, antithrombotic, analgesic, antimicrobial, and anti-cancer properties. Due to its diverse applications in medicine, cosmetics, food, and agriculture, SA is considered a highly promising biomolecule. As a precursor of aromatic compounds, SA plays a crucial role in various metabolic pathways within organisms. Traditional methods for producing SA mainly rely on plant extraction (such as star anise) or chemical synthesis. However, these approaches face challenges such a high costs, low efficiency, and environmental concerns. With the ongoing advancements in synthetic biology and metabolic engineering, the production of SA through metabolic engineering has emerged as a focal point of research, offering a more sustainable and cost-effective alternative. This paper reviews the applications and production methods of SA, with a particular emphasis on recent progress and optimization strategies in its biosynthesis.

shikimic acid pathway  /  shikimic acid  /  biosynthesis  /  production strategies  /  literature informatics
Huanghui XIA, Shumei CUI, Jianzhong HUANG. Research progress in shikimic acid biosynthesis[J]. Acta Microbiologica Sinica, 2025 , 65 (3) : 916 -938 . DOI: 10.13343/j.cnki.wsxb.20240640
Funding
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  • National Key Research and Development Program of China(2022YFD1802104)
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Year 2025 volume 65 Issue 3
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Article Info
doi: 10.13343/j.cnki.wsxb.20240640
  • Receive Date：2024-10-16
  • Online Date：2026-02-10
  • Published：2025-03-04
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History
  • Received：2024-10-16
  • Accepted：2024-12-03
Funding
National Key Research and Development Program of China(2022YFD1802104)
Affiliations
    Engineering Research Center of Industrial Microbiology, Ministry of Education, National and Local United Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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