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Research progress of gut microbiota in non-alcoholic fatty liver disease
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Xiaoqin DENG, Runqiu JIANG, Xiangyun LI
Acta Microbiologica Sinica | 2025, 65(9) : 3859 - 3868
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Acta Microbiologica Sinica | 2025, 65(9): 3859-3868
• Review •
Research progress of gut microbiota in non-alcoholic fatty liver disease
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Xiaoqin DENG, Runqiu JIANG, Xiangyun LI
Affiliations
  • Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250154
Outline
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Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease around the world, and it has a complex disease progression. Recent studies have demonstrated that gut microbiota (GM) plays a crucial role in the pathogenesis of NAFLD. The theory of gut-liver axis provides a theoretical basis for understanding the relationship between GM and the liver. Dysbiosis of GM leads to immune dysfunction, inflammatory responses, damaged gut barrier, and insulin resistance, all of which promote the development and progression of NAFLD. Furthermore, GM can participate in the development and progression of NAFLD through endotoxemia and abnormal metabolism of short chain fatty acids, bile acids, and choline. How to mitigate NAFLD by modifying GM has become the focus of current research, and the measures include fecal microbiota transplantation, probiotics, prebiotics, Chinese herbal medicines, and lifestyle interventions. The review focuses on the impact of the pathological state of GM on NAFLD and discusses the research progress in GM-targeted therapy for NAFLD. It is expected to provide new strategies and targets for the prevention and treatment of NAFLD.

non-alcoholic fatty liver disease  /  gut-liver axis  /  gut microbiota  /  gut microbiota-derived metabolites
Xiaoqin DENG, Runqiu JIANG, Xiangyun LI. Research progress of gut microbiota in non-alcoholic fatty liver disease[J]. Acta Microbiologica Sinica, 2025 , 65 (9) : 3859 -3868 . DOI: 10.13343/j.cnki.wsxb.20250154
Funding
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  • National Natural Science Foundation of China(82100613)
  • National Natural Science Foundation of China(82173100)
  • National Natural Science Foundation of China(82472819)
  • Research Fund Project of Postdoctor in Anhui Province(2023B705)
  • Anhui Excellent Youth Fund(2408085J043)
  • First Affiliated Hospital of Anhui Medical University (2023) Talent Introduction Program Research Start-up Funding for Medical Innovation(1713)
Appendix
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Year 2025 volume 65 Issue 9
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195
72
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Article Info
doi: 10.13343/j.cnki.wsxb.20250154
  • Receive Date：2025-02-27
  • Online Date：2026-02-07
  • Published：2025-09-04
Article Data
Affiliations
History
  • Received：2025-02-27
  • Accepted：2025-04-08
Funding
National Natural Science Foundation of China(82100613)
National Natural Science Foundation of China(82173100)
National Natural Science Foundation of China(82472819)
Research Fund Project of Postdoctor in Anhui Province(2023B705)
Anhui Excellent Youth Fund(2408085J043)
First Affiliated Hospital of Anhui Medical University (2023) Talent Introduction Program Research Start-up Funding for Medical Innovation(1713)
Affiliations
    Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

Corresponding:

*E-mail: LI Xiangyun,
JIANG Runqiu,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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