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Research progress in Akkermansia muciniphila and glucose and lipid metabolism
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Yueshuang ZHAO1, 2, Tiegang XIAO2, Yang ZHANG2, Jialu LYU2, Xiangyu DU1, 2, Jiahua WEI2, Kaili LIU2, Li ZHANG2, Jun XU2, Bing WANG2
Acta Microbiologica Sinica | 2025, 65(9) : 3889 - 3898
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Acta Microbiologica Sinica | 2025, 65(9): 3889-3898
• Review •
Research progress in Akkermansia muciniphila and glucose and lipid metabolism
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Yueshuang ZHAO1, 2, Tiegang XIAO2, Yang ZHANG2, Jialu LYU2, Xiangyu DU1, 2, Jiahua WEI2, Kaili LIU2, Li ZHANG2, Jun XU2, Bing WANG2
Affiliations
  • 1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
  • 2 Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250173
Outline
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Akkermansia muciniphila, a major gut microorganism, has garnered significant attention for its involvement in the regulation of glucose and lipid metabolism. Glucose and lipid metabolic disorders, characterized by hyperglycemia and dyslipidemia, are caused by multiple factors. These disorders are not only prevalent globally but also increasingly common among young people in China, representing a major public health concern. This review systematically elaboratesthe research progress in A. muciniphila and glucose and lipid metabolism from the perspective of its mechanisms of action. Specifically, the review summarizes the regulatory pathways through which A. muciniphila influence glucose and lipid metabolism, assesses how pharmaceuticals that enhance A. muciniphila abundance affect metabolic parameters, and discusses advances in the bioengineering of A. muciniphila. By synthesizing current research findings, this review aims to provide valuable insights for understanding glucose and lipid metabolic disorders and developing novel therapeutic approaches for related diseases.

Akkermansia muciniphila  /  glucose metabolism  /  lipid metabolism
Yueshuang ZHAO, Tiegang XIAO, Yang ZHANG, Jialu LYU, Xiangyu DU, Jiahua WEI, Kaili LIU, Li ZHANG, Jun XU, Bing WANG. Research progress in Akkermansia muciniphila and glucose and lipid metabolism[J]. Acta Microbiologica Sinica, 2025 , 65 (9) : 3889 -3898 . DOI: 10.13343/j.cnki.wsxb.20250173
Funding
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  • National Science and Technology Major Special Project(2023ZD0509305)
  • Shanghai 2023 “Science and Innovation Action Plan” Natural Science Foundation(23ZR1448400)
  • Shanghai Health Commission Traditional Chinese Medicine Research Project(2024BJ003)
Appendix
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Year 2025 volume 65 Issue 9
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Article Info
doi: 10.13343/j.cnki.wsxb.20250173
  • Receive Date：2025-03-04
  • Online Date：2026-02-07
  • Published：2025-09-04
Article Data
Affiliations
History
  • Received：2025-03-04
  • Accepted：2025-03-30
Funding
National Science and Technology Major Special Project(2023ZD0509305)
Shanghai 2023 “Science and Innovation Action Plan” Natural Science Foundation(23ZR1448400)
Shanghai Health Commission Traditional Chinese Medicine Research Project(2024BJ003)
Affiliations
    1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
    2 Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Corresponding:

*E-mail: XU Jun:
WANG Bing:
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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