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Antimicrobial resistance, virulence genes, and evolution of Salmonella Wandsworth isolates from Jiangsu
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Chengchao LI1, 2, Xinyue WU1, 2, Fuzhong WANG1, 2, Ruiyang XU1, 2, Zhengzhong XU1, 2, Chengkun ZHENG1, 2, Xin’an JIAO1, 2, Xiang CHEN1, 2
Acta Microbiologica Sinica | 2025, 65(9) : 4224 - 4232
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Acta Microbiologica Sinica | 2025, 65(9): 4224-4232
• Data Paper •
Antimicrobial resistance, virulence genes, and evolution of Salmonella Wandsworth isolates from Jiangsu
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Chengchao LI1, 2, Xinyue WU1, 2, Fuzhong WANG1, 2, Ruiyang XU1, 2, Zhengzhong XU1, 2, Chengkun ZHENG1, 2, Xin’an JIAO1, 2, Xiang CHEN1, 2
Affiliations
  • 1 Jiangsu Key Lab of Zoonosis/Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China
  • 2 Key Lab of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, Jiangsu, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250149
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[Objective] To investigate the antimicrobial resistance phenotypes and genomic characteristics of Salmonella Wandsworth isolates from fecal and bedding samples across four dairy farms in Jiangsu. [Methods] Serotyping was reconfirmed by the slide agglutination method, and antimicrobial susceptibility was determined via the Kirby-Bauer disk diffusion assay. Whole-genome sequencing was performed, followed by bioinformatics analysis to characterize multilocus sequence typing (MLST) profiles, antimicrobial resistance genes, and virulence genes. A phylogenetic tree was built based on core genome single nucleotide polymorphisms (SNPs) to assess genetic homology among strains and elucidate population evolutionary relationships between prevalent strains from diverse sources. [Results] Seven Salmonella Wandsworth isolates were identified, all exhibiting susceptibility to 14 tested antimicrobials. The isolates were identified as ST1498 by MLST, harboring the aminoglycoside resistance gene aac(6')-Iaa and 106 virulence genes spanning eight functional categories. The analysis of SNPs revealed high genetic homogeneity, with six isolates clustering closely and three isolates showing a difference of zero in SNPs. [Conclusion] This study isolated a rare ST1498-type Salmonella Wandsworth from dairy farms in Jiangsu. The isolates demonstrate susceptibility to all tested antimicrobials while harboring a resistance gene and multiple virulence genes. These findings highlight the necessity of enhanced Salmonella surveillance in dairy farms to mitigate potential epidemiological risks.

Salmonella Wandsworth  /  whole-genome sequencing  /  antimicrobial resistance genes  /  virulence genes
Chengchao LI, Xinyue WU, Fuzhong WANG, Ruiyang XU, Zhengzhong XU, Chengkun ZHENG, Xin’an JIAO, Xiang CHEN. Antimicrobial resistance, virulence genes, and evolution of Salmonella Wandsworth isolates from Jiangsu[J]. Acta Microbiologica Sinica, 2025 , 65 (9) : 4224 -4232 . DOI: 10.13343/j.cnki.wsxb.20250149
Funding
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  • National Key Research and Development Program of China(2022YFC2604200)
  • Jiangsu Agriculture Science and Technology Innovation Fund(CX(21)1004)
  • “111” Project(D18007)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
Appendix
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Year 2025 volume 65 Issue 9
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140
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Article Info
doi: 10.13343/j.cnki.wsxb.20250149
  • Receive Date：2025-02-26
  • Online Date：2026-02-07
  • Published：2025-09-04
Article Data
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History
  • Received：2025-02-26
  • Accepted：2025-03-24
Funding
National Key Research and Development Program of China(2022YFC2604200)
Jiangsu Agriculture Science and Technology Innovation Fund(CX(21)1004)
“111” Project(D18007)
Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
Affiliations
    1 Jiangsu Key Lab of Zoonosis/Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China
    2 Key Lab of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, Jiangsu, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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