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Molecular regulation of the retinoic acid-inducible gene-I -like receptor signaling pathway by protein methylation
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Jia LEI1, Le LI2, Furuo DONG1, Lixia HUI1, Aixin LI1
Acta Microbiologica Sinica | 2025, 65(9) : 3834 - 3847
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Acta Microbiologica Sinica | 2025, 65(9): 3834-3847
• Review •
Molecular regulation of the retinoic acid-inducible gene-I -like receptor signaling pathway by protein methylation
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Jia LEI1, Le LI2, Furuo DONG1, Lixia HUI1, Aixin LI1
Affiliations
  • 1 School of Laboratory Medicine, Shandong Second Medical University, Weifang, Shandong, China
  • 2 School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250129
Outline
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Outbreaks and epidemics of RNA viruses represent a serious threat to human health. The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) signaling pathway plays a pivotal role in host resistance to viral infections. RLRs recognize the RNA produced after viral invasion, initiating the activation of the RLR signaling pathway to combat viral infection. Abnormal activation of this pathway is linked to the development of chronic inflammation, damage to immune organs, and autoimmune diseases. To prevent the disruption of RLR signaling pathway activation, the body has established a comprehensive regulatory system with the objective of stabilizing the RLR signaling pathway. Protein methylation represents a significant post-translational modification of proteins, playing a pivotal role in numerous biological processes. The methylation of molecules in the RLR signaling pathway has been demonstrated to be indispensable for the body to regulate the RLR signaling pathway. This paper presents a comprehensive review of the latest research findings on the role of protein methylation in regulation of the RLR signaling pathway, offering novel insights into the host regulation of the RLR signaling pathway in combatting viral infection.

RLR signaling pathway  /  protein methylation  /  methyltransferases
Jia LEI, Le LI, Furuo DONG, Lixia HUI, Aixin LI. Molecular regulation of the retinoic acid-inducible gene-I -like receptor signaling pathway by protein methylation[J]. Acta Microbiologica Sinica, 2025 , 65 (9) : 3834 -3847 . DOI: 10.13343/j.cnki.wsxb.20250129
Funding
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  • Natural Science Foundation of Shandong Province(ZR2023QH354)
  • Natural Science Foundation of Shandong Province(ZR2022QH126)
  • Youth Innovation Team of Colleges and Universities in Shandong Province(2023KJ248)
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Year 2025 volume 65 Issue 9
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156
59
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Article Info
doi: 10.13343/j.cnki.wsxb.20250129
  • Receive Date：2025-02-21
  • Online Date：2026-02-07
  • Published：2025-09-04
Article Data
Affiliations
History
  • Received：2025-02-21
  • Accepted：2025-04-27
Funding
Natural Science Foundation of Shandong Province(ZR2023QH354)
Natural Science Foundation of Shandong Province(ZR2022QH126)
Youth Innovation Team of Colleges and Universities in Shandong Province(2023KJ248)
Affiliations
    1 School of Laboratory Medicine, Shandong Second Medical University, Weifang, Shandong, China
    2 School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China

Corresponding:

*E-mail: HUI Lixia,
LI Aixin,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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