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Advances in diagnostic strategies for the pathogens ofLegionnaires’ disease
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Jingyu WU1, Lina HUANG1, Songying OUYANG1, 2, Dongmei WANG1
Acta Microbiologica Sinica | 2025, 65(9) : 3821 - 3833
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Acta Microbiologica Sinica | 2025, 65(9): 3821-3833
• Review •
Advances in diagnostic strategies for the pathogens ofLegionnaires’ disease
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Jingyu WU1, Lina HUANG1, Songying OUYANG1, 2, Dongmei WANG1
Affiliations
  • 1 College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China
  • 2 Biomedical Research Center of South China, Fujian Normal University, Fuzhou, Fujian, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250090
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Legionnaires’ disease, a serious pulmonary infection caused by Legionella, requires early diagnosis for effective treatment and favorable outcomes. Laboratory diagnostic methods primarily encompass isolation and culture, antigen detection, nucleic acid detection, and serological testing. Although isolation and culture are considered the gold standard, it is characterized by low sensitivity and extended culture duration. Antigen detection offers simple and fast operation but necessitates improved specificity. Nucleic acid detection, although being highly sensitive, has complex operation and high costs. Serological testing provides limited value for early diagnosis. Urine antigen detection, extensively employed globally, is limited to the detection of Legionella pneumophila serogroup I. Novel nucleic acid detection technologies, including digital PCR, isothermal amplification, and next-generation sequencing, present promising applications. Future research should aim to develop more streamlined, rapid, and sensitive detection methods to enhance the early diagnostic rate of Legionnaires’ disease.

Legionnaires’ disease  /  nucleic acid amplification tests  /  antigen detection
Jingyu WU, Lina HUANG, Songying OUYANG, Dongmei WANG. Advances in diagnostic strategies for the pathogens ofLegionnaires’ disease[J]. Acta Microbiologica Sinica, 2025 , 65 (9) : 3821 -3833 . DOI: 10.13343/j.cnki.wsxb.20250090
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  • National Natural Science Foundation of China(82172287)
Appendix
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Year 2025 volume 65 Issue 9
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Article Info
doi: 10.13343/j.cnki.wsxb.20250090
  • Receive Date：2025-02-10
  • Online Date：2026-02-07
  • Published：2025-09-04
Article Data
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History
  • Received：2025-02-10
  • Accepted：2025-05-08
Funding
National Natural Science Foundation of China(82172287)
Affiliations
    1 College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China
    2 Biomedical Research Center of South China, Fujian Normal University, Fuzhou, Fujian, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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