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Shiraia fruiting body-associated fungi regulate the biosynthesis of hypocrellin A
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Liping ZHENG1, Hongyao JI2, Jianqin ZHOU2, Jianwen WANG2, *
Acta Microbiologica Sinica | 2025, 65(4) : 1758 - 1773
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Acta Microbiologica Sinica | 2025, 65(4): 1758-1773
• Development and application of microbial resources •
Shiraia fruiting body-associated fungi regulate the biosynthesis of hypocrellin A
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Liping ZHENG1, Hongyao JI2, Jianqin ZHOU2, Jianwen WANG2, *
Affiliations
  • 1.Gold Mantis School of Architecture, Soochow University, Suzhou, Jiangsu, China
  • 2.College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China
Published: 2025-04-04 doi: 10.13343/j.cnki.wsxb.20250009
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The fruiting bodies of fungi of genus Shiraia inhabiting bamboo have a medicinal use in traditional Chinese medicine. Hypocrellin A (HA), the main bioactive perylenequinone pigment from S. bambusicola fruiting bodies is a novel non-porphyrin photosensitizer with antitumor and antimicrobial properties. [Objective] To investigate the effects of Shiraia fruiting body-associated fungi on HA biosynthesis and develop a co-culture method for enhancing HA production. [Methods] Shiraia fruiting body-associated fungi were isolated and the strains influencing HA biosynthesis were screened by a plate confrontation assay. The effects of intracellular and extracellular metabolites of the strains on HA production were evaluated. A co-culture system for Shiraia sp. S9 and associated fungi was established and optimized for enhancing HA production. [Results] There were 34 fungal strains including 6 host Shiraia strains isolated from the fruiting bodies. Among them, Fusarium sp. SF12 and its extracellular polysaccharides significantly promoted HA biosynthesis. Fusarium sp. SF12 did not noticeably affect the growth of Shiraia sp. S9 but regulated HA synthesis by upregulating the transcription levels of key enzyme genes involved in HA biosynthesis. The total HA yield was enhanced to 209.46 mg/L on day 8 after adding spores (100 cell/mL) from Fusarium sp. SF12 to the Shiraia culture at the time point of 24 h, which was 1.93 times that of the control. [Conclusion] There are diverse fungi in Shiraia fruiting bodies. The co-culture of the associated fungus Fusarium sp. SF12 and the host Shiraia sp. S9 is a new technique to improve HA production.

Shiraia  /  fruiting bodies  /  associated fungi  /  hypocrellin A  /  co-culture
Liping ZHENG, Hongyao JI, Jianqin ZHOU, Jianwen WANG. Shiraia fruiting body-associated fungi regulate the biosynthesis of hypocrellin A[J]. Acta Microbiologica Sinica, 2025 , 65 (4) : 1758 -1773 . DOI: 10.13343/j.cnki.wsxb.20250009
Funding
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  • National Natural Science Foundation of China(82073955)
  • National Natural Science Foundation of China(81773696)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
Appendix
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Year 2025 volume 65 Issue 4
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109
44
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Article Info
doi: 10.13343/j.cnki.wsxb.20250009
  • Receive Date：2025-01-05
  • Online Date：2026-02-06
  • Published：2025-04-04
Article Data
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History
  • Received：2025-01-05
  • Accepted：2025-02-19
Funding
National Natural Science Foundation of China(82073955)
National Natural Science Foundation of China(81773696)
Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
Affiliations
    1.Gold Mantis School of Architecture, Soochow University, Suzhou, Jiangsu, China
    2.College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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