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Advances in the interaction mechanisms between rough Brucella and host organisms
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Linjiao LI1, 2, Qian WANG1, 2, 3, Dongxu QIU1, 2, Minghe LIU4, Yu FENG1, 2, Xuezheng FAN1, 2, Jiabo DING1, 2, Shijing SUN6, Farong XU1, 5, Hui JIANG1, 2
Acta Microbiologica Sinica | 2025, 65(7) : 2830 - 2840
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Acta Microbiologica Sinica | 2025, 65(7): 2830-2840
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Advances in the interaction mechanisms between rough Brucella and host organisms
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Linjiao LI1, 2, Qian WANG1, 2, 3, Dongxu QIU1, 2, Minghe LIU4, Yu FENG1, 2, Xuezheng FAN1, 2, Jiabo DING1, 2, Shijing SUN6, Farong XU1, 5, Hui JIANG1, 2
Affiliations
  • 1.Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
  • 2.Key Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Beijing, China
  • 3.College of Veterinary Medicine, Shandong Agricultural University, Tai’an, Shandong, China
  • 4.China Institute of Veterinary Drug Control, Beijing, China
  • 5.Beijing Center for Animal Disease Prevention and Control, Beijing, China
  • 6.Beijing Biopharmaceutical Technology Center, Zhaofenghua Biotech (Nanjing) Co. , Ltd. , Beijing，China
Published: 2025-07-04 doi: 10.13343/j.cnki.wsxb.20240848
Outline
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Brucellosis is a zoonotic disease caused by Brucella. Brucella can replicate within various host cells and evade the host immune system, which underpins its pathogenicity. Rough Brucella strains, characterized by the absence or inadequacy of the O-antigen chain, exhibit incomplete lipopolysaccharide structures, precluding the production of anti-lipopolysaccharide antibodies. This distinguishing feature facilitates differential diagnosis and has attracted considerable attention. Rough Brucella can invade and manipulate the host immune system via low endotoxin activity, lysosomal escape, and resistance to complement attacks. Nevertheless, comprehensive investigations into the host immune responses, rough Brucella-host interaction mechanisms, and virulence gene functions of rough Brucella remain scarce. This article elucidates the intracellular parasitism process of rough Brucella and the molecular mechanisms underlying their interactions with hosts, with the aim of offering insights for the development of effective vaccines against rough Brucella.

rough Brucella  /  intracellular parasitism  /  innate immunity  /  adaptive immunity
Linjiao LI, Qian WANG, Dongxu QIU, Minghe LIU, Yu FENG, Xuezheng FAN, Jiabo DING, Shijing SUN, Farong XU, Hui JIANG. Advances in the interaction mechanisms between rough Brucella and host organisms[J]. Acta Microbiologica Sinica, 2025 , 65 (7) : 2830 -2840 . DOI: 10.13343/j.cnki.wsxb.20240848
Funding
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  • Agricultural Science and Technology Innovation Program(CAAS-ZDRW202410)
  • Key Research and Development Plan of Ningxia Hui Autonomous Region(2024BBF02014)
  • Beijing Rural Revitalization Agricultural Science and Technology Project(NY2502170200)
Appendix
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Year 2025 volume 65 Issue 7
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Article Info
doi: 10.13343/j.cnki.wsxb.20240848
  • Receive Date：2024-12-28
  • Online Date：2026-02-06
  • Published：2025-07-04
Article Data
Affiliations
History
  • Received：2024-12-28
  • Accepted：2025-02-24
Funding
Agricultural Science and Technology Innovation Program(CAAS-ZDRW202410)
Key Research and Development Plan of Ningxia Hui Autonomous Region(2024BBF02014)
Beijing Rural Revitalization Agricultural Science and Technology Project(NY2502170200)
Affiliations
    1.Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
    2.Key Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Beijing, China
    3.College of Veterinary Medicine, Shandong Agricultural University, Tai’an, Shandong, China
    4.China Institute of Veterinary Drug Control, Beijing, China
    5.Beijing Center for Animal Disease Prevention and Control, Beijing, China
    6.Beijing Biopharmaceutical Technology Center, Zhaofenghua Biotech (Nanjing) Co. , Ltd. , Beijing，China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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