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Research progress on the mechanism of biofilm formation of Streptococcus mutans mediated by fluid shear stress
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Yige SUN1, 2, 3, Qingguo QI4, Tiezhou HOU1, 2, 3, Le QIANG1, 2, 3
Acta Microbiologica Sinica | 2025, 65(7) : 2799 - 2810
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Acta Microbiologica Sinica | 2025, 65(7): 2799-2810
• Review •
Research progress on the mechanism of biofilm formation of Streptococcus mutans mediated by fluid shear stress
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Yige SUN1, 2, 3, Qingguo QI4, Tiezhou HOU1, 2, 3, Le QIANG1, 2, 3
Affiliations
  • 1.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
  • 2.Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
  • 3.Department of Cariology and Endodontics, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
  • 4.Jinan Keen Dental Hospital, Jinan, Shandong, China
Published: 2025-07-04 doi: 10.13343/j.cnki.wsxb.20240806
Outline
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This article explores the dynamic regulation of fluid shear stress on the biofilm formation of Streptococcus mutans, aiming to elucidate the pathogenic mechanism of this bacterium and provide references for the prevention of dental caries. S. mutans is a major cariogenic bacterium in the oral cavity, and it destroys the tooth tissue by forming biofilms and producing acids by metabolism. Studies have shown that fluid shear stress can regulate the physical structure, secretion of extracellular polymeric substances, adhesion, and quorum sensing of biofilms, thereby affecting the pathogenicity. This study provides a theoretical basis for deeply understanding the ecological adaptability of pathogens in fluid environments and the development of new intervention measures in clinical practice.

fluid dynamics  /  Streptococcus mutans  /  biofilm  /  quorum sensing system  /  dental caries
Yige SUN, Qingguo QI, Tiezhou HOU, Le QIANG. Research progress on the mechanism of biofilm formation of Streptococcus mutans mediated by fluid shear stress[J]. Acta Microbiologica Sinica, 2025 , 65 (7) : 2799 -2810 . DOI: 10.13343/j.cnki.wsxb.20240806
Funding
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  • National Natural Science Foundation of China(42307568)
  • General Research Project of Xi’an Science and Technology Plan Medical Research(23YXYJ0150)
  • Yong Teacher Foundation of College of Stomatology, Xi’an Jiaotong University(080122)
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Year 2025 volume 65 Issue 7
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Article Info
doi: 10.13343/j.cnki.wsxb.20240806
  • Receive Date：2024-12-12
  • Online Date：2026-02-06
  • Published：2025-07-04
Article Data
Affiliations
History
  • Received：2024-12-12
  • Accepted：2025-03-05
Funding
National Natural Science Foundation of China(42307568)
General Research Project of Xi’an Science and Technology Plan Medical Research(23YXYJ0150)
Yong Teacher Foundation of College of Stomatology, Xi’an Jiaotong University(080122)
Affiliations
    1.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
    2.Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
    3.Department of Cariology and Endodontics, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
    4.Jinan Keen Dental Hospital, Jinan, Shandong, China

Corresponding:

*E-mail: QIANG Le,
HOU Tiezhou,
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https://castjournals.cast.org.cn/joweb/wswxb/EN/10.13343/j.cnki.wsxb.20240806
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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