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Mechanisms of bacterial infection mediated by the lipoprotein PplA of Listeria monocytogenes
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Yucong LIU1, Lifeng YANG2, Gengjia REN1, Qinjia SANG1, Houhui SONG1, Jing SUN1, Lingli JIANG2, Changyong CHENG1, *, Mianmian CHEN1, *
Acta Microbiologica Sinica | 2025, 65(8) : 3540 - 3551
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Acta Microbiologica Sinica | 2025, 65(8): 3540-3551
• Research Article •
Mechanisms of bacterial infection mediated by the lipoprotein PplA of Listeria monocytogenes
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Yucong LIU1, Lifeng YANG2, Gengjia REN1, Qinjia SANG1, Houhui SONG1, Jing SUN1, Lingli JIANG2, Changyong CHENG1, *, Mianmian CHEN1, *
Affiliations
  • 1.Key Laboratory of Applied Biotechnology on Animal Science & Veterinary Medicine of Zhejiang Province, Zhejiang Engineering Research Center for Veterinary Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, the Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China
  • 2.Ningbo College of Health Sciences, Ningbo, Zhejiang, China
Published: 2025-08-04 doi: 10.13343/j.cnki.wsxb.20240715
Outline
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[Objective] We employed the wild-type strain of Listeria monocytogenes, the lipoprotein gene pplA- deleted strain, and the complementary strain to investigate the role of PplA in the infection of L. monocytogenes. [Methods] We compared the hemolytic capacity, cell adhesion and invasion, intracellular proliferation, cell-to-cell migration, mouse organ colonization, transcription levels of virulence factors in mouse organs, and transcription levels of quorum sensing-related genes among wild-type, pplA-deleted, and complementary strains to explore the role of PplA in the infection of L. monocytogenes. [Results] After the deletion of pplA, L. monocytogenes showed no significant change in intracellular proliferation or cell-to-cell migration. However, its hemolytic capacity, cell adhesion and invasion, mouse organ colonization, and transcription levels of virulence factors such as plcB, hly, and prfA in mouse organs were significantly reduced. Moreover, the transcription levels of quorum sensing-related genes agrA, agrB, agrC, and luxS were altered in the pplA-deleted strain. [Conclusion] Thelipoprotein PplA is involved in the virulence regulation and affects the pathogenicity of L. monocytogenes.

Listeria monocytogenes  /  lipoprotein PplA  /  cell infection  /  virulence regulation
Yucong LIU, Lifeng YANG, Gengjia REN, Qinjia SANG, Houhui SONG, Jing SUN, Lingli JIANG, Changyong CHENG, Mianmian CHEN. Mechanisms of bacterial infection mediated by the lipoprotein PplA of Listeria monocytogenes[J]. Acta Microbiologica Sinica, 2025 , 65 (8) : 3540 -3551 . DOI: 10.13343/j.cnki.wsxb.20240715
Funding
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  • National Key Research and Development Program of China(2023YFD1801800)
  • Ningbo Natural Science Foundation(2023J241)
  • Natural Science Foundation of Zhejiang Province(LY23C180002)
Appendix
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Year 2025 volume 65 Issue 8
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144
60
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Article Info
doi: 10.13343/j.cnki.wsxb.20240715
  • Receive Date：2024-11-12
  • Online Date：2026-02-06
  • Published：2025-08-04
Article Data
Affiliations
History
  • Received：2024-11-12
  • Accepted：2025-04-30
Funding
National Key Research and Development Program of China(2023YFD1801800)
Ningbo Natural Science Foundation(2023J241)
Natural Science Foundation of Zhejiang Province(LY23C180002)
Affiliations
    1.Key Laboratory of Applied Biotechnology on Animal Science & Veterinary Medicine of Zhejiang Province, Zhejiang Engineering Research Center for Veterinary Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, the Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China
    2.Ningbo College of Health Sciences, Ningbo, Zhejiang, China

Corresponding:

*E-mail: CHEN Mianmian,
CHENG changyong,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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