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Yeast asci lysate as an immunostimulatory dietary supplement
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Congcong DU1, Yuqing LI1, Guoyu LIU1, 2, Xiaoman ZHOU1, Nakanishi Hideki1, *
Acta Microbiologica Sinica | 2025, 65(8) : 3657 - 3670
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Acta Microbiologica Sinica | 2025, 65(8): 3657-3670
• Research Article •
Yeast asci lysate as an immunostimulatory dietary supplement
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Congcong DU1, Yuqing LI1, Guoyu LIU1, 2, Xiaoman ZHOU1, Nakanishi Hideki1, *
Affiliations
  • 1.School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
  • 2.Beijing Key Laboratory of the Innovative Development of Functional Staple and Nutritional Intervention for Chronic Disease, China National Research Institute of Food and Fermentation Industries Co. , Ltd. , Beijing, China
Published: 2025-08-04 doi: 10.13343/j.cnki.wsxb.20250057
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Yeast β-glucan has been widely used as a dietary supplement for its multiple biological activities, including immune stimulation. Previous studies in our laboratory have shown that yeast chs3Δ spores exposed in the glucan layer can activate immune effects more effectively than trophoblasts. However, chs3Δ spores are formed within the ascospores and are encapsulated by the ascospore cell wall, which greatly limits their direct application. [Objective] To explore whether the lysates of chs3Δ asci have the potential to be used as novel immune-stimulating dietary supplements. [Methods] We prepared chs3Δ asci lysates by ultrasonic freeze drying, enzymatic freeze drying, and enzymatic-assisted ultrasonic freeze drying and then explored their immune effects in depth. [Results] The chs3Δ asci lysate prepared by ultrasonic freeze drying induced the highest level of inflammatory cytokines compared with the vegetative cell lysate and chs3Δ spores, and the asci lysate achieved immunostimulatory responses through activation of Dectin-1 receptor. Further studies showed that the chs3Δ asci lysate also exhibited immunostimulatory activity and trained immunity-inducing ability in mice. [Conclusion] The chs3Δ asci lysate has great potential as a highly effective immunostimulatory dietary supplement.

Saccharomyces cerevisiae  /  yeast β-glucan  /  dietary supplement  /  immune stimulation  /  Dectin-1
Congcong DU, Yuqing LI, Guoyu LIU, Xiaoman ZHOU, Nakanishi Hideki. Yeast asci lysate as an immunostimulatory dietary supplement[J]. Acta Microbiologica Sinica, 2025 , 65 (8) : 3657 -3670 . DOI: 10.13343/j.cnki.wsxb.20250057
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  • National Natural Science Foundation of China(32071467)
Appendix
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Year 2025 volume 65 Issue 8
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Article Info
doi: 10.13343/j.cnki.wsxb.20250057
  • Receive Date：2025-01-20
  • Online Date：2026-02-06
  • Published：2025-08-04
Article Data
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History
  • Received：2025-01-20
  • Accepted：2025-03-03
Funding
National Natural Science Foundation of China(32071467)
Affiliations
    1.School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
    2.Beijing Key Laboratory of the Innovative Development of Functional Staple and Nutritional Intervention for Chronic Disease, China National Research Institute of Food and Fermentation Industries Co. , Ltd. , Beijing, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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