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Research progress in regulation of secondary metabolite synthesisby two-component systems in Streptomyces
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Ziyue LIU1, Jiao WANG1, Le ZHAO1, Daqun LIU1, 2, Yaning LI1, *
Acta Microbiologica Sinica | 2025, 65(8) : 3468 - 3491
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Acta Microbiologica Sinica | 2025, 65(8): 3468-3491
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Research progress in regulation of secondary metabolite synthesisby two-component systems in Streptomyces
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Ziyue LIU1, Jiao WANG1, Le ZHAO1, Daqun LIU1, 2, Yaning LI1, *
Affiliations
  • 1.Technological Innovation Center for Biological Control of Crop Diseases and Insect Pests of Hebei Province, National Engineering Research Center for Agriculture in Northern Mountainous Areas, College of Plant Protection, Hebei Agricultural University, Baoding, Hebei, China
  • 2.Graduate School, Chinese Academy of Agricultural Sciences, Beijing, China
Published: 2025-08-04 doi: 10.13343/j.cnki.wsxb.20250042
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Streptomyces can produce various active secondary metabolites, which can be widely used in medical, industrial, agricultural, and other fields. The secondary metabolite synthesis in Streptomyces is regulated by pathway-specific, pleiotropic, and global regulatory genes. The two-component system, as the main signal transduction system in prokaryotes, participates in various physiological and biochemical reactions of Streptomyces and can globally regulate secondary metabolites. The deletion or overexpression of specific two-component system genes can significantly affect the biosynthesis of secondary metabolites. Identifying the functions of two-component systems and elucidating their regulatory mechanisms can contribute to enhancing the production efficiency of secondary metabolites by genetic engineering. This paper reviews the research trends of two-component systems in various Streptomyces species such as Streptomyces albidoflavus in recent years and particularly summarizes and elaborates on the regulatory mechanisms of their secondary metabolite synthesis.

Streptomyces  /  two-component system  /  secondary metabolites  /  regulatory mechanism
Ziyue LIU, Jiao WANG, Le ZHAO, Daqun LIU, Yaning LI. Research progress in regulation of secondary metabolite synthesisby two-component systems in Streptomyces[J]. Acta Microbiologica Sinica, 2025 , 65 (8) : 3468 -3491 . DOI: 10.13343/j.cnki.wsxb.20250042
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  • National Natural Science Foundation of China(32272605)
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Year 2025 volume 65 Issue 8
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Article Info
doi: 10.13343/j.cnki.wsxb.20250042
  • Receive Date：2025-01-15
  • Online Date：2026-02-06
  • Published：2025-08-04
Article Data
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History
  • Received：2025-01-15
  • Accepted：2025-03-20
Funding
National Natural Science Foundation of China(32272605)
Affiliations
    1.Technological Innovation Center for Biological Control of Crop Diseases and Insect Pests of Hebei Province, National Engineering Research Center for Agriculture in Northern Mountainous Areas, College of Plant Protection, Hebei Agricultural University, Baoding, Hebei, China
    2.Graduate School, Chinese Academy of Agricultural Sciences, Beijing, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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