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Research progress in the therapeutic effects and mechanisms of probiotics in HPV infection
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Chongyue WANG1, 2, Yuwei WU3, Xinqiang XIE2, Ying LI2, *, Qingping WU2, *
Acta Microbiologica Sinica | 2025, 65(2) : 437 - 452
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Acta Microbiologica Sinica | 2025, 65(2): 437-452
• Review •
Research progress in the therapeutic effects and mechanisms of probiotics in HPV infection
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Chongyue WANG1, 2, Yuwei WU3, Xinqiang XIE2, Ying LI2, *, Qingping WU2, *
Affiliations
  • 1 School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, China
  • 2 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
  • 3 Guangdong Kehuan Biotechnology Co. , Ltd. , Guangzhou, Guangdong, China
Published: 2025-02-04 doi: 10.13343/j.cnki.wsxb.20240472
Outline
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Human papillomavirus (HPV) infection is a major global health challenge closely related to diseases such as cervical cancer. At present, there is no effective treatment for HPV, and thus it is essential to develop new antiviral biological agents to reduce the harm of HPV infection. Recent studies have revealed a complex relationship between HPV infection and the human microbiome, suggesting that HPV infection can disrupt the balance of the microbiome and cause immune dysfunction in the body. In recent years, studies have found that oral or topical use of specific probiotic strains can reduce HPV titers in patients and prevent viral infection-related cancers, demonstrating probiotics as a new class of anti-HPV preparations with a development value. From the molecular biological characteristics of HPV, this article systematically summarizes the pathogenic mechanism of HPV infection and explains the antiviral mechanisms of probiotics from four perspectives: inhibiting virus replication, regulating immune responses, enhancing the mucosal barrier function, and reshaping the human microbiome. This review aims to provide theoretical references for the efficient breeding and mechanism analysis of anti-HPV probiotics.

human papillomavirus  /  immune escape  /  microbiome  /  probiotics  /  antiviral mechanism
Chongyue WANG, Yuwei WU, Xinqiang XIE, Ying LI, Qingping WU. Research progress in the therapeutic effects and mechanisms of probiotics in HPV infection[J]. Acta Microbiologica Sinica, 2025 , 65 (2) : 437 -452 . DOI: 10.13343/j.cnki.wsxb.20240472
Funding
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  • National Key Research and Development Program of China(2023YFF1104110)
  • Guangdong Academy of Sciences Technology Innovation Platform Special Project(2022GDASZH-2022020402-01)
Appendix
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Year 2025 volume 65 Issue 2
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Article Info
doi: 10.13343/j.cnki.wsxb.20240472
  • Receive Date：2024-07-30
  • Online Date：2026-02-05
  • Published：2025-02-04
Article Data
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History
  • Received：2024-07-30
  • Accepted：2024-10-17
Funding
National Key Research and Development Program of China(2023YFF1104110)
Guangdong Academy of Sciences Technology Innovation Platform Special Project(2022GDASZH-2022020402-01)
Affiliations
    1 School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, China
    2 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
    3 Guangdong Kehuan Biotechnology Co. , Ltd. , Guangzhou, Guangdong, China

Corresponding:

*E-mail: WU Qingping,
LI Ying,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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