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Research progress in combined application of traditional Chinese medicines and antifungal agents in treating Cryptococcus infections
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Yihan YANG1, Yaxin MAO2, Xinping XU1, *
Acta Microbiologica Sinica | 2025, 65(2) : 537 - 550
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Acta Microbiologica Sinica | 2025, 65(2): 537-550
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Research progress in combined application of traditional Chinese medicines and antifungal agents in treating Cryptococcus infections
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Yihan YANG1, Yaxin MAO2, Xinping XU1, *
Affiliations
  • 1 Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
  • 2 Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
Published: 2025-02-04 doi: 10.13343/j.cnki.wsxb.20240533
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Cryptococcus, a genus of invasive fungi with global distribution, have caused serious public health problems. Notably, Cryptococcus neoformans (Cryptococcus neoformans, C. neoformans) represents the main pathogenic species of Cryptococcus. The infection of C. neoformans can cause pulmonary cryptococcosis and cryptococcal meningitis with high mortality rates. The commonly used antifungal drugs are polyenes, flucytosine, echinocandins, and azoles, which have limited efficacy and may induce resistance when being used alone in clinical practice. Therefore, researchers have studied combined therapy. They have discovered that the combinations of some traditional Chinese medicines and natural plant extracts and derivatives with the commonly used antifungal drugs demonstrate synergistic effects in the treatment of cryptococcosis. This paper reviews the research progress in the combined application of antifungal drugs and traditional Chinese medicines.

Cryptococcusneoformans  /  combined therapy  /  antifungal drugs  /  traditional Chinese medicine  /  antifungal mechanism
Yihan YANG, Yaxin MAO, Xinping XU. Research progress in combined application of traditional Chinese medicines and antifungal agents in treating Cryptococcus infections[J]. Acta Microbiologica Sinica, 2025 , 65 (2) : 537 -550 . DOI: 10.13343/j.cnki.wsxb.20240533
Funding
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  • National Natural Science Foundation of China(82360399)
Appendix
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Year 2025 volume 65 Issue 2
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Article Info
doi: 10.13343/j.cnki.wsxb.20240533
  • Receive Date：2024-08-27
  • Online Date：2026-02-05
  • Published：2025-02-04
Article Data
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History
  • Received：2024-08-27
  • Accepted：2024-11-01
Funding
National Natural Science Foundation of China(82360399)
Affiliations
    1 Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
    2 Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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