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Advances in metabolic engineering of yeast for succinic acid production
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Ziyun GU, Yongsheng TANG, Xiulai CHEN*
Acta Microbiologica Sinica | 2025, 65(2) : 467 - 488
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Acta Microbiologica Sinica | 2025, 65(2): 467-488
• Review •
Advances in metabolic engineering of yeast for succinic acid production
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Ziyun GU, Yongsheng TANG, Xiulai CHEN*
Affiliations
  • Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
Published: 2025-02-04 doi: 10.13343/j.cnki.wsxb.20240597
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Succinic acid is an important four-carbon dicarboxylic acid widely used in the food, pharmaceutical, and chemical industries. Compared with petrochemical-based chemical synthesis methods, microbial fermentation offers an economical and environmentally friendly alternative for succinic acid production, presenting significant potential for industrial applications. Due to the robust environmental tolerance, yeast cell factories for succinic acid production have gradually become a research focus. This review centers on succinic acid production in yeast, providing an overview of metabolic engineering and regulatory strategies for constructing yeast cell factories. The research hotspots in this field include the development of succinic acid biosynthetic pathways, optimization of cofactor supply, and modification of transmembrane transport systems. Additionally, recent advances in cost-effective succinic acid biosynthesis and approaches to enhance yeast strain robustness are discussed. Finally, the review provides the prospects of yeast in succinic acid biosynthesis.

metabolic engineering  /  microbial cell factories  /  yeast  /  succinic acid
Ziyun GU, Yongsheng TANG, Xiulai CHEN. Advances in metabolic engineering of yeast for succinic acid production[J]. Acta Microbiologica Sinica, 2025 , 65 (2) : 467 -488 . DOI: 10.13343/j.cnki.wsxb.20240597
Funding
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  • National Key Research and Development Program of China(2021YFC2103500)
  • Fundamental Research Funds for the Central Universities(JUSRP622001)
Appendix
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Year 2025 volume 65 Issue 2
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243
94
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Article Info
doi: 10.13343/j.cnki.wsxb.20240597
  • Receive Date：2024-09-28
  • Online Date：2026-02-05
  • Published：2025-02-04
Article Data
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History
  • Received：2024-09-28
  • Accepted：2024-11-11
Funding
National Key Research and Development Program of China(2021YFC2103500)
Fundamental Research Funds for the Central Universities(JUSRP622001)
Affiliations
    Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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