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Research progress in regulation of picornavirus infections by host kinases
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Xue'er DOU1, 2, 3, Ruiya LIAN1, 2, 3, 4, Na WANG1, 2, 3, Shasha LI1, 2, 3, 4, *, Huixia LI1, 2, 3, *
Acta Microbiologica Sinica | 2025, 65(2) : 551 - 566
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Acta Microbiologica Sinica | 2025, 65(2): 551-566
• Review •
Research progress in regulation of picornavirus infections by host kinases
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Xue'er DOU1, 2, 3, Ruiya LIAN1, 2, 3, 4, Na WANG1, 2, 3, Shasha LI1, 2, 3, 4, *, Huixia LI1, 2, 3, *
Affiliations
  • 1 Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
  • 2 Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
  • 3 Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
  • 4 School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou, Gansu, China
Published: 2025-02-04 doi: 10.13343/j.cnki.wsxb.20240564
Outline
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Kinases are the major category of proteins that regulate intracellular signal transduction by phosphorylating target proteins. They catalyze the transfer of phosphate groups of high-energy donor molecules to specific substrates, serving as the key regulators of cell functions. Host kinases constitute a large protein family with diverse functions, guiding the activation, subcellular localization, and conformational changes of target proteins. In recent years, more and more studies have shown that host kinases play a regulatory role in the processes of picornavirus infections. Picornaviruses can cause a variety of diseases in human and animals. They lead to serious public health problems and huge economic burden in a global scope. A comprehensive understanding of the infection processes of picornaviruses is helpful for the prevention and treatment of these diseases. This paper reviews the research progress in the regulation of picornavirus infections by host kinases, aiming to comprehensively elucidate the mechanisms for interactions between host kinases and picornaviruses. At the same time, we discuss the potential of host kinases as effective treatments and drug targets against picornaviruses infection, aiming to provide implications for the development of new anti-picornavirus agents and vaccines in the future.

host kinases  /  picornaviruses  /  regulation  /  infection mechanisms
Xue'er DOU, Ruiya LIAN, Na WANG, Shasha LI, Huixia LI. Research progress in regulation of picornavirus infections by host kinases[J]. Acta Microbiologica Sinica, 2025 , 65 (2) : 551 -566 . DOI: 10.13343/j.cnki.wsxb.20240564
Funding
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  • Gansu Youth Science and Technology Fund(23JRRA1742)
  • Gansu Youth Science and Technology Fund(21JR1RA212)
  • Fundamental Research Funds for the Central Universities(31920240116)
  • Talent Introduction Research Projects of Northwest Minzu University(xbmuyjrc2020021)
Appendix
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Year 2025 volume 65 Issue 2
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142
48
Cite this Article
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Article Info
doi: 10.13343/j.cnki.wsxb.20240564
  • Receive Date：2024-09-13
  • Online Date：2026-02-05
  • Published：2025-02-04
Article Data
Affiliations
History
  • Received：2024-09-13
  • Accepted：2024-10-18
Funding
Gansu Youth Science and Technology Fund(23JRRA1742)
Gansu Youth Science and Technology Fund(21JR1RA212)
Fundamental Research Funds for the Central Universities(31920240116)
Talent Introduction Research Projects of Northwest Minzu University(xbmuyjrc2020021)
Affiliations
    1 Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
    2 Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
    3 Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
    4 School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou, Gansu, China

Corresponding:

*E-mail: LI Shasha,
LI Huixia,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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