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Advances in the molecular mechanisms of Mycobacteriumtuberculosis in regulating antigen presentation in dendritic cells
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Hui MA1, Yinjuan SONG1, Ling MA2, Yuefeng CHU1
Acta Microbiologica Sinica | 2025, 65(5) : 1905 - 1917
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Acta Microbiologica Sinica | 2025, 65(5): 1905-1917
• Review •
Advances in the molecular mechanisms of Mycobacteriumtuberculosis in regulating antigen presentation in dendritic cells
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Hui MA1, Yinjuan SONG1, Ling MA2, Yuefeng CHU1
Affiliations
  • 1.State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
  • 2.Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China
Published: 2025-05-04 doi: 10.13343/j.cnki.wsxb.20240678
Outline
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Tuberculosis is an ancient zoonotic disease that poses a serious threat to the health of humans and animals worldwide. Mycobacteriumtuberculosis (Mtb) is the primary causative agent of tuberculosis. As a bridge between innate and adaptive immunity, dendritic cells (DCs) play a pivotal role in controlling Mtb infection by utilizing their potent antigen-presenting capacity to activate the adaptive immune response of the host and thus resist further infection. In recent years, more and more studies have shown that Mtb can evade host immune defenses by regulating DC differentiation and maturation, interfering with phagocytosis and autophagy, and inhibiting the expression of antigen presentation-related molecules, thus causing persistent infection. This review summarizes the current research on the molecular mechanisms of Mtb in regulating DC antigen presentation, aiming to provide insights for further study of Mtb-DC interaction mechanism and development of prevention and control strategies for tuberculosis.

Mycobacteriumtuberculosis  /  dendritic cells  /  antigen presentation  /  molecular mechanisms
Hui MA, Yinjuan SONG, Ling MA, Yuefeng CHU. Advances in the molecular mechanisms of Mycobacteriumtuberculosis in regulating antigen presentation in dendritic cells[J]. Acta Microbiologica Sinica, 2025 , 65 (5) : 1905 -1917 . DOI: 10.13343/j.cnki.wsxb.20240678
Funding
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  • National Key Research and Development Program of China(2023YFD1800700)
  • Natural Science Foundation of Gansu Province(22JR5RA712)
  • Science and Technology Major Project of Gansu Province(22ZD6NA001)
  • Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2021-LVRI)
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Year 2025 volume 65 Issue 5
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251
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Article Info
doi: 10.13343/j.cnki.wsxb.20240678
  • Receive Date：2024-11-02
  • Online Date：2026-02-05
  • Published：2025-05-04
Article Data
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History
  • Received：2024-11-02
  • Accepted：2025-02-09
Funding
National Key Research and Development Program of China(2023YFD1800700)
Natural Science Foundation of Gansu Province(22JR5RA712)
Science and Technology Major Project of Gansu Province(22ZD6NA001)
Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2021-LVRI)
Affiliations
    1.State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
    2.Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China

Corresponding:

E-mail: CHU Yuefeng,
SONG Yinjuan,
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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